原发性中枢神经系统淋巴瘤预后分析  

Prognostic factors of primary central nervous system B-cell lymphoma

作　　者：程静[1] 张正祥[1] 石群立[1] 赵有财[1] 涂频[1] 周晓军[1] 王修来[1] 

机构地区：[1]南京大学医学院临床学院(南京军区南京总医院)病理科,江苏南京210002

出　　处：《医学研究生学报》2008年第11期1187-1190,1194,I0016,共6页Journal of Medical Postgraduates

基　　金：江苏省六大人才高峰重点课题基金资助项目(批准号:2005A5)

摘　　要：目的:从临床及组织病理学角度探讨原发性中枢神经系统淋巴瘤(PCNSL)的预后因素。方法:复习47例PCNSL患者的临床资料,应用CD3和CD20进行免疫组化染色,观察其组织病理学特点,对临床资料、肿瘤坏死及血管周围反应性T淋巴细胞浸润(RPVI)情况与预后的关系进行分析。结果:47例PCNSL患者中,25例(53.2%)有RPVI,13例(27.7%)有肿瘤坏死。单因素及多因素统计学分析均显示,年龄<60岁和RPVI阳性的患者与预后好相关(P<0.05)。结论:RPVI和年龄是影响中枢神经系统淋巴瘤的有效预后因子。RPVI指标简单易得,有潜在的治疗指导价值,值得进一步的生物学研究。Objective： To investigate clinical and histopathological factors of the prognosis of primary central nervous system lymphoma （PCNSL）. Methods： The clinicopathological data of 47 cases of PCNSL and the related literature were reviewed. CD3 and CD20 antigens were immunohistochemically labeled on paraffin-embedded sections. Results ： Reactive perivascular T-cell infiltration （RPVI） was observed in 25 （53.2%） and tumor necrosis （TN） in 13 （27.7%） of the 47 cases. Univariate and multivariate analyses showed a better prognosis in the PCNSL patients aged 〈 60 years and with RPVI-positive lesions （P 〈 0.05）. Conclusion ： Age and RPVI are valuable prognostic factors of PCNSL. RPVI indexes can be easily obtained and, in view of its potential therapeutic implications, deserves further biological characterization.

关 键 词：中枢神经系统 淋巴瘤 病理学 预后原发性 

分 类 号：R733.4[医药卫生—肿瘤]