S100A4蛋白在肝癌组织中的表达及临床意义  

Expression of S100A4 protein in hepatocellular carcinoma and its clinical implications

作　　者：郝向芳[1] 李红[1] 葛超[1] 胡晨[2] 陈陶阳[3] 李锦军[1] 

机构地区：[1]上海交通大学肿瘤研究所癌基因及相关基因国家重点实验室,上海200032 [2]浙江大学附属第一医院普外科,杭州310003 [3]启东肝癌防治研究所,启东226200

出　　处：《肿瘤》2008年第11期955-958,共4页Tumor

基　　金：国家自然科学基金资助项目(编号:30731160004);“九七三”计划重大项目(编号:2002CB513104);上海市卫生局科技发展基金项目(编号:054033)

摘　　要：目的:探讨S100A4蛋白在肝细胞癌、肝硬化、癌旁组织及正常肝组织中的表达及临床意义。方法:用组织芯片技术结合免疫组织化学法检测S100A4蛋白在肝癌相关组织中的表达差异,采用统计学方法分析其表达差异的临床意义。结果:免疫组织化学检测发现,S100A4蛋白在人原发性肝细胞癌、硬化肝组织、癌旁肝组织中表达较高,在正常肝组织中表达则很低,表达阳性率分别为70.2%、54.4%、41.7%和0.0%;统计学分析结果表明,S100A4蛋白表达影响肝癌患者的术后生存期,低表达患者的生存期比高表达患者延长。结论:S100A4蛋白在肝癌及相关组织中的表达率依次为,肝细胞癌>癌旁肝>肝硬化>正常肝,在非微血管侵袭肝癌患者中S100A4阳性表达可明显降低其术后生存率。Objective ：To explore the expressions of S100A4 protein in hepatocellular carcinoma （HCC）, cirrhotic liver, adjacent non-cancerous liver and normal liver tissues and their clinical implications. Methods： Tissue microarray combined with immunohistochemistry （IHC） was used to evaluate the differential expressions of S100A4 protein in HCC-related tissues, and their clinical implications were statistically analyzed. Results： Immunohistochemical staining showed that the positive staining of S100A4 protein was higher in the specimens of primary HCC （70.2%）, liver cirrhosis （54.4%）, and adjacent non-cancerous liver tissues （41.7%） compared with that in normal liver tissues （0.0%）. Biological statistic analysis revealed that S100A4 protein expression influenced the survival time of HCC patients. The patients with weak expression of S100A4 had longer survival time than those with over-expression of S100A4 protein （ P = 0.040）. Conclusion： The order of the expression levels of S100A4 protein in HCC-related tissues is ： HCC 〉 adjacent non-cancerous liver 〉 cirrhotic liver 〉 normal liver. In HCC patients without hepatic microvaseular invasion, positive expression of S100A4 protein significantly decreases their postoperative survival rate.

关 键 词：癌 肝细胞 免疫组织化学 S100A4蛋白 

分 类 号：R735.7[医药卫生—肿瘤]