利维爱对绝经后妇女氧化低密度脂蛋白及内皮功能的影响  

The effect of tibolone tablets on ox-LDL and function of endothelial cells in postmenopausal women

作　　者：田文艳[1] 武红利[1] 钟亚丽[1] 苏立凯[1] 代聪伟[2] 

机构地区：[1]河北大学附属医院,河北保定071000 [2]河北省人民医院

出　　处：《中国老年学杂志》2008年第21期2111-2112,共2页Chinese Journal of Gerontology

基　　金：河北省科技厅科技基金(03276196D-52)

摘　　要：目的观察利维爱治疗对绝经后妇女血清氧化型低蜜度脂蛋白(ox-LDL)、一氧化氮(NO)、内皮素-1(ET-1)水平的影响。方法选择有更年期症状的绝经后妇女138例,随机分为利维爱组(利维爱2.5mg/d)和对照组。利维爱组治疗前及治疗2年后检测血清ox-LDL、NO、ET-1水平。结果129例完成观察和治疗。利维爱治疗2年后血ox-LDL(P<0.01),ET(P<0.05)显著降低,NO显著升高(P<0.05)。结论利维爱对动脉内皮细胞有保护作用,对预防动脉粥样硬化有效。Objective To assess the effect of tibolone on oxidized low density lipoprotein （ox-LDL）, nitric oxide （NO）, endothelin （ET）-1 of serum in postmenopausal women. Methods 138 symptomatic postmenopausal women were randomly divided into tibolone （2. 5 mg/d） and control group. Fasting blood samples were drawn at baseline and the end of the follow-up period - 2 years later for ox-LDL, NO, ET-1. Results 129 subjects finished observation and treatment. Tibolone group had significantly decreased the level of ox-LDL （P 〈 0. 01 ）, ET-1 （ P 〈 0.05 ）, and increased NO level （ P 〈 0. 05 ） 2 years later. Conclusions Tibolone treatment can protect endothelial cells of artery and thus appears to be useful in preventing atherosclerosis.

关 键 词：利维爱 氧化低密度脂蛋白 一氧化氮 内皮素-1 

分 类 号：R74[医药卫生—神经病学与精神病学]