蛛网膜下腔出血患者血浆肿瘤坏死因子-α和内皮素含量动态变化及其临床意义  

Clinical significance of plasma TNF-α and ET levels in patients with subarachnoid hemorrhage

作　　者：吉四辈[1] 田小军[1] 李合华[1] 宋志秀[1] 翟锴华[1] 马铭心[1] 

机构地区：[1]新乡医学院第一附属医院神经,河南省卫辉市453100

出　　处：《中国综合临床》2008年第12期1188-1190,共3页Clinical Medicine of China

基　　金：河南省教育厅科技攻关项目（2008B320006）;河南省新乡市科委科技攻关项目（07S047）

摘　　要：目的观察蛛网膜下腔出血患者血浆中肿瘤坏死因子-α（TNF-α）及内皮素（ET）水平的动态变化。方法采用ELISA法和放免法分别测定45例蛛网膜下腔出血患者第1、3、7、14、21天的血浆TNF-α和ET水平。结果蛛网膜下腔出血患者血浆TNF-α和ET水平较正常对照组高（均P〈0．01），第3～7天升高明显，第14天降低，但第21天仍高于对照组。Hunt-Hess分级Ⅲ-Ⅴ级患者第3、14、21天血浆TNF-α和ET均较Ⅰ、Ⅱ级者高（P〈0．01）。结论TNF-α和ET作为免疫因素参与了蛛网膜下腔出血的病理生理过程，提示TNF-α和ET拮抗剂治疗蛛网膜下腔出血及预防其所致脑血管痉挛将是一条可能途径。Objective To study the plasma TNF-α and endothelin （ET） levels in patient with subarachnoid hemorrhage（SAH）. Methods The plasma TNF-α and ET levels were measured by ELISA and radioimmunity at 1,3,7,14 and 21 d after onset of SAH in 45 patients. Results The plasma TNF-α and ET levels in patients with SAH were higher than the normal controls（P 〈 0.01）, among which the highest levels appeared at 3 d and 7 d, and the levels of plasma TNF-α and ET in patients with SAH were decreased at 14 d. Those of high Hunt-Hess grade groups was higher than those of lower grade - groups（ P 〈0.01 ）. Conclusion The plasma TNF-α and ET levels are significantly elevated in the patients with SAH,which suggests that TNF-α and ET may play an important role in the pathogenesis of SAH, and which suggests that is one of the possible ways to prevent and treat cardiovascular spasm （ CVS ） after SAH by inhibiting TNF-α and ET.

关 键 词：蛛网膜下腔出血 肿瘤坏死因子-Α 内皮素 

分 类 号：R743.35[医药卫生—神经病学与精神病学]