两种材质异体骨移植治疗创伤性骨缺损的临床效果  

The clinical analysis of repairing traumatic bony defect with grafting materials of different allograft bone

作　　者：孔志刚[1] 于海泉[1] 

机构地区：[1]河北医科大学第三医院骨伤科,石家庄市050051

出　　处：《河北医药》2008年第11期1656-1659,共4页Hebei Medical Journal

基　　金：河北省卫生厅科研基金项目(编号:07080)

摘　　要：目的探讨大段异体骨复合自体骨和异体松质骨颗粒复合自体红骨髓移植治疗四肢创伤性骨缺损的方法及临床效果。方法自2002～2006年,我们应用同种异体骨移植治疗创伤所性骨缺损及骨不愈合38例,根据骨缺损的部位及程度选择不同的方法,其中大段同种异体骨复合自体骨治疗大段骨缺损16例,同种异体松质骨颗粒复合自体红骨髓移植治疗局限性骨缺损22例。结果获得10个月以上随访38例,37例骨性愈合。大段异体骨复合自体骨移植15例骨折愈合,愈合时间10～25个月,平均11.5个月,感染复发1例。局限性骨缺损松质骨颗粒复合自体骨髓移植22例骨折全部愈合。愈合时间3～13个月,平均6个月。结论同种异体骨为一种良好骨植入材料,长段异体骨复合自体骨后可用于创伤造成的大段骨缺损。异体松质骨颗粒复合自体红骨髓移植可用于修复陈旧性骨折骨不愈合和局限性骨缺损。Objective To evaluate the method and the clinical outcome of repairing traumatic bone defect of the limbs by using big allograft combined with autograft bone and allogeneic cancellous bone combined with autologous red marrow.Methods 38 patients of traumatic bony defect were treated with allogeneic bone transplantation from February 2002 to April 2006.Different treatment approachs were taken according to the locations and degrees of bone defect in patients with traumatic bone defect.16 cases were treated with big allograft combined with autograft bone,and 22 cases of partial bone defect were treated with allogeneic cancellous bone combined with autologous red marrow.Results All the patients were followed up for more than 10 months,and 37 cases had bone healing.The healing period was 10～25 months（average 11.5 months） for 15 cases treated with big allograft combined with autograft,and 3～13 months（average 6 months） for 22 cases of partial bone defect treated with allogeneic cancellus combined with autologous red marrow.Only one case was failed with infection.Conclusion Allograft bone is a good materials for bone implantation,and long allograft bone combined with autologous bone can be used to repair large bone defects,while cancellus combined with autologous red marrow can be used to treat old fracture not healing and repair partial bone defect.

关 键 词：同种异体骨 自体骨 自体红骨髓 移植 骨折 骨缺损 

分 类 号：R739.82[医药卫生—肿瘤] R683.05[医药卫生—临床医学]