肿瘤坏死因子对睡眠的影响及其机制分析  

EFFECTS AND MECHANISM OF TUMOR NECROSIS FACTOR ON ANIMAL’S SLEEP

作　　者：李树新[1] 库宝善[1] 李中华[1] 林志彬[1] 

机构地区：[1]北京医科大学北京,100083

出　　处：《神经科学》1997年第4期157-160,共4页Chinese Journal of Neuroscience

摘　　要：本研究采用两种动物模型观察了肿瘤坏死因子（TNF）对睡眠的影响，并对其机制进行了初步的探讨。结果表明TNF可使小鼠自主活动明显减少，明显延长成巴比妥钠诱导的小鼠睡眠时间；TNF经静脉注射或脑室内注射均可延长家兔睡眠时间，其中以延长深睡眠为主，作用可持续12小时。为揭示TNF促进睡眠的机制，观察了TNF对脑内单胺神经递质的影响，结果表明，TNF可使小鼠脑内5－HT及其代谢产物5－HIAA含且明显增高；TNF还可使大鼠皮层5－HT、5—HIAA含量增高；使海马及下丘脑的5－HIAA含量增加，但5－HT的含量无明显变化；用优降宁阻断5一HT降解后，TNF可使小鼠脑内5—HT的合成速率增加。这些结果提示，TNF可能是通过促进5—HT的合成而影响睡眠的。Tumor necrosis factor (TNF) could aeduce the spontaneous activity of mice and Prolong the sleeptime induced by sodium pentobarbital. It could also increase the time of NREM sleep, especially deep sleep of rabbits. The level of 5 - HT and 5 - HIAA in mouse brain were elevated after TNF administration. TNF also increased the concentration of 5 - HT and 5 - HIAA in rat cerebral cortex. TNF did not affect the concentration of5 - HT in rat hippocampus and hypothalamus, but elevated the level of 5 - HIAA in these brain regions. Afterblockade of 5 - HT degradation with pargyline, TNF can increase the Synthesis rate of 5 - HT in mice. All the results suggest that the sleep promoting effect of TNF is due to that it could enhance the synthesis of 5 - HT.

关 键 词：肿瘤坏死因子 深睡眠 5-HT 神经免疫调节 

分 类 号：R338.63[医药卫生—人体生理学]