急性癫痫大鼠脑脊液中四种氨基酸含量的变化  

CHANGES OF CONTENTS OF FOUR AMINO-ACIDS IN CSF OF ACUTE EPILEPSY RATS

作　　者：朱家祥[1] 周厚纶[1] 朱长庚[1] 王炜[2] 何善述[2] 江卫国[2] 刘朝[3] 

机构地区：[1]同济医科大学解剖学教研室,脑研究室,武汉430030 [2]同济医科大学解剖学生物化学教研室,武汉430030 [3]同济医科大学附属协和医院中心实验室,武汉430030

出　　处：《神经科学》1997年第4期183-185,共3页Chinese Journal of Neuroscience

基　　金：国家自然科学重点项目!No.39330210

摘　　要：本文用神经递质HPLC荧光法测定了急性致病大鼠脑脊液中四种氨基酸的含且及应用NMDA受体阻断剂MK—801后对上述指标的影响。结果：急性致痫组动物脑脊液中GIU明显增高（P＜0．05）。其它三种氨基酸变化不明显。使用MK—801后，脑脊液中Gin合且有所下降。提示：马迈内酯致痴与脑内GIu升高有关。Contents of four amino-acids in CSF of Coriaria Lactone (CL)-induced acute epilepsy ratswere measured by means of HPLC method. The results showed that the content of glutamic acid was obviously increased (P< 0. 05), but in others the changes were not remarkable following CL. After administration of NMDAreceptor antagonist MK-801 intraventricularly the content of glutamic acid in CSF was decreased

关 键 词：马桑内酯 癫痫 高效液相色谱 脑脊液 谷氨酸 大鼠 

分 类 号：R742.102[医药卫生—神经病学与精神病学]