NG108-15细胞的离子通道及其在研究活性物质作用中的应用  

ION CHANNELS AT NEUROBLASTOMA × GLIOMA NG108-15 CELL AND ITS APPLICATION TO ANALYZING THE ACTIONS OF BIOACTIVE SUBSTANCES

作　　者：胡谦[1] 施玉梁[1] 

机构地区：[1]中国科学院上海生理研究所,上海200031

出　　处：《神经科学》1997年第4期186-191,共6页Chinese Journal of Neuroscience

基　　金：国家自然科学基金!39470238;八五攀登项目;"脑功能及其细胞和分子机制"资助

摘　　要：由神经母细胞瘤和神经胶质细胞瘤融合杂交的细胞系NG108-15细胞（neuroblastoma×gliomahybridcell），经分化后具成熟神经细胞的特性，存在多种在神经细胞膜发现的离子通道和受体，现已被作为神经细胞模型广泛地应用于神经生物学研究。本文就已在该细胞膜上发现的离子通道的种类及其性质做了介绍，并列举实例，说明它在分析生物活性物质作用机制中的应用。Neuroblastoma×glioma hybrid cell line, NG108-15 cell formed by the fusion of mouse neuroblastoma and rat glioma expresses many properties of mature neurons after being differentiated by N6O2-dibutyryladenosine 3', 5'-cyclic monophosphats (dbcAMP) or prostaglandin E1 (PGE1). The differentiated NG108-15cells display a wide range of ion channels and receptors found in neural cells and are being used widely in neurobiologcal researches. This paper describes the ion-channels characterized at NG108-15 cell and their properties aswell as some examples of using the cell line to Study the actions of bioactive subeboces.

关 键 词：离子通道 NG108-15细胞 生物活性物质 

分 类 号：R329.26[医药卫生—人体解剖和组织胚胎学]