肺癌患者血清VEGF和EGF检测及其临床意义  

Levels of VEGF and EGF in the Serum of Patients with Lung Cancer and Its Clinical Significance

作　　者：信淑珍[1] 滕琳[2] 欧阳修河[1] 

机构地区：[1]山东省滨州市人民医院呼吸科,山东滨州256610 [2]山东省潍坊市人民医院,山东潍坊261000

出　　处：《医学临床研究》2008年第11期1973-1975,共3页Journal of Clinical Research

摘　　要：【目的】检测血管内皮生长因子(VEGF)与表皮生长因子(EGF)在肺癌患者血清中的表达水平,探讨它们与肿瘤分型、临床分期的关系及两者相关性。【方法】应用ELISA法检测34例肺癌患者、29例良性肺疾病患者及30例健康对照组的血清VEGF水平,同时用RIA法检测其EGF水平。【结果】肺癌患者的血清VEGF与EGF表达水平均高于良性肺疾病患者及健康人(P<0.05);但两者表达水平与肿瘤的病理类型、TNM分期、远处转移等无关。二者呈显著相关性。【结论】血清VEGF与EGF表达水平测定有助于肺癌的辅助诊断及治疗。[Objective] To evaluate the serum levels of VEGF and EGF in lung carcinoma and to analysis their correlation with clinical stages as well as histological patterns.[Methods]Serum VEGF and EGF of 34 patients with untreated primary lung cancer,29 patients with benign pulmonary diseases,and 30 controls were analyzed with ELISA and RIA method.[Results]The serum levels of VEGF and EGF in lung cancer were higher than those of healthy controls and benign pulmonary diseases（P〈0.05）.There was significant correlation between serum VEGF and EGF which were not related to histological patterns,stages and distant metastasis.[Conclusion] Serum VEGF and EGF levels can contribute to early diagnosis and treatment of lung cancer.

关 键 词：肺肿瘤/血液 内皮生长因子/血液 表皮生长因子-尿抑胃素/血液 

分 类 号：R734.2[医药卫生—肿瘤]