小型猪滑脉实验教学模型的建立  

A minipig based experimental teaching model for slippery pulse

作　　者：陈冬志[1] 牛欣[2] 杨学智[2] 董晓英[2] 张志国[2] 高蔚[2] 司银楚[2] 

机构地区：[1]河北大学医学部,保定071000 [2]北京中医药大学,北京100029

出　　处：《中华中医药杂志》2008年第12期1047-1049,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金资助项目(No.30371720);国家自然科学基金重点项目(No.60431020);"十一五"国家科技支撑计划项目(No.2007BAI07A23)

摘　　要：目的:建立小型猪滑脉实验教学模型。方法:用静脉滴注低分子右旋糖酐10%葡萄糖注射液造模。由两名有经验中医师采用双盲法从小型猪腋动脉切取平脉和滑脉脉象,同时选用NX-8型多功能脉图仪以最适取法提取腋动脉脉图有关时阈参数:主波高(HB)、升支最大斜率(MSAB)、降支最大斜率(MSBC)、降中峡高/主波高(HE/HB)、降中波波幅(HFF’),主波宽(TW)。结果:小型猪滑脉脉率较平脉稍有增快,节律规整,三部应指有力,应指时间短,态势畅利,如珠走盘,举按皆得。与造模前平脉比较,造模后小型猪脉图显示升支陡峭,B波高而窄,D波微小不明显,E谷的相对高度较低,F波明显。HB增高(P<0.01),MSAB、MSBC增大(P<0.01),HFF’增高(P<0.05);HE/HB减小(P<0.01),TW减小(P<0.01)。结论:采用静脉滴注低分子右旋糖酐10%葡萄糖注射液的方法可以造成小型猪脉滑变模型,且方法简单,重复稳定性好,易于操作。Objective： To establish experimental teaching model for slippery pulse by mini-pig. Methods： The model of slippery pulse was established by driping low molecule dextran in vein.The normal and slippery pulse were extracted from axil artery of mini-pig by two experienced traditional Chinese physician through double blind method. Meanwile, the correlative parameters of pulse graph of axil artery such as MSAB, MSBC, HFF, HE/HB and TW were extracted through optimizational extraction method by using NX-8 multifunctional sphygmograph. Results： The pulse rate of slippery pulse of mini-pig was slightly fast than that of normal pulse.The rhythm of slippery pulse was regularity, the finger sensation was powerful, and the pulse syate was smooth. Compared with the normal pluse, the pulse graph of slippery pluse displayed a steep ascend ramus, high and narrow B wave ,tiny D wave,lower E valley and obvious F wave. liB, MSAB and MSBC increased （P〈0.01）, HFF＇increased （P〈0.05）, HE/HB and TW decreased （P〈0. 01）. Conclusion： The slippery pulse model of mini-pig can be replicatied successfully by using the method of driping low molecule dextran in vein.The method was simple and convenient, the model was repeatable and stable.

关 键 词：小型猪 滑脉 实验 教学 模型 实验研究 

分 类 号：R-332[医药卫生]