不同ER基因哺乳期妇女骨密度影响因素分析  

Bone mineral density of lactating women with ER genotypes and its related factors

作　　者：李芳[1] 龚洁[1] 曾晶[1] 孙惠玲[1] 黄振武[2] 

机构地区：[1]湖北省武汉市疾病预防控制中心,430024 [2]中国疾病预防控制中心营养与食品安全所

出　　处：《中国公共卫生》2008年第12期1473-1475,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金面上项目(30571573)

摘　　要：目的在湖北省武汉地区筛选不同雌激素受体基因(ER基因)PvuII和XbaI联合型别哺乳期妇女,检测其骨骼骨密度水平,分析其骨密度的主要影响因素。方法使用ER基因PvuⅡ和XbaI酶切多态性分析,筛选不同ER基因PvuⅡ和XbaI联合型别哺乳期妇女101名,使用双能X线吸收骨密度测定仪测量腰椎和左髋的骨密度,并通过3d,24h的膳食调查计算其平均每日钙摄入量。结果101名受试者中骨质疏松率为20.8%;6种基因型别中PPxx的骨密度均值低于其他几种基因型别,但差异无统计学意义;大转子(Troch)相对其他部位骨质更容易丢失(P=0.002)。多元线性回归分析显示,每日钙摄入量、体质指数(BMI)和哺乳天数是哺乳期妇女腰椎骨密度值的主要影响因素(标准偏回归系数b′分别为0.242,0.236,-0.192;P值分别为0.014,0.017,0.047)。结论PPxx基因型别是哺乳期妇女骨密度下降的相对弱势群体,对大转子的骨密度监测有利于早期发现哺乳期妇女缺钙的个体或人群,对哺乳期妇女进行系统充足的钙剂补充是降低其骨质丢失及提高骨密度的主要途径。Objective To investigate the bone mineral density（BMD） of lactating women with different ER Pvu Ⅱ and Xba Ⅰ genotypes and to analyse the main influential factors of BMD. Methods 101 healthy lactating women of Han nationality in Wuhan were selected in the study. The ER Pvu II and Xba I genotypes were determined by PCR - RFLPs. The BMD of lumbar spine and left hip were measured by dual - energy X - ray absorptionmetry. Calcium intakes were calculated from a 3 day food consumption questionnaire. Results The osteoporosis rate of 101 lactating women was 20.8 %. The mean BMD values of the PPxx genotypes were lower than that of the other five genotypes, but there was no significant difference between them. The bone loss rate of troch was significantly higher than that of other sites（ P = 0. 002）. Calcium intake, Body Mass In- dex （BMI）, lactating time were significantly related to lumbar spine BMD via multiple linear regression（ the standardized coefficients were 0. 242, 0.236 and - 0.192, respectively and P values were 0. 014, 0. 017 and 0. 047, respectively）. Conclusion Some variation of the ER gene links to the descent of BMD, especially in PPxx genotype. Troch BMD monitoring is propitious to find early bone loss of lactating women. To give systematic calcium supplementary to lactating women can prevent the bone loss and osteoporosis.

关 键 词：ER基因多态性 哺乳 骨密度 钙摄入 

分 类 号：R181.2[医药卫生—流行病学]