慢性萎缩性胃炎患者胃黏膜上皮细胞中PCNA、EGF、VEGF的表达及意义  

Expression of PCNA,EGF and VEGF in chronic atrophic gastritis and their clinical significance

作　　者：孙永红[1] 孙良华[1] 黄文波[1] 乔颜春[1] 张圆圆[1] 

机构地区：[1]潍坊医学院附属医院,山东潍坊261031

出　　处：《山东医药》2008年第40期4-6,共3页Shandong Medical Journal

基　　金：山东省中医药科技发展计划项目(2005-237)。

摘　　要：目的观察慢性胃炎胃黏膜上皮细胞增殖细胞核抗原(PCNA)、表皮生长因子(EGF)及血管内皮生长因子(VEGF)的表达特点,提高慢性萎缩性胃炎(CAG)的诊治水平。方法应用免疫组织化学SP法检测PCNA、EGF、VEGF在12例慢性浅表性胃炎(CSG)3、4例单纯CAG、28例CAG伴肠上皮化生、30例CAG伴不典型增生患者胃粘膜上皮细胞中的表达。结果从CSG、CAG到肠上皮化生、不典型增生,随胃黏膜病变加重,PCNA、EGF、VEGF的表达阳性率呈递增趋势,CSG与CAG者比较三者表达无显著差异;IM患者三者表达明显高于CSG及CAG者,P<0.05;DYS者较伴肠上皮化生者PCNALI升高P<0.05;EGF、VEGF表达无显著差异。结论伴肠上皮化生和不典型增生可能通过PCNA、EGF、及VEGF的过度表达而促进胃粘膜细胞增殖和恶性转化,此对于CAG的病理诊断及临床治疗具有一定的价值。Objective To investigate the expression of PCNA,EGF and VEGF in gastric mueosa of patients with CAG and their clinical value. Methods 12 cases of normal control, 34 cases of CAG,28 cases of IM and 30 cases of DYS were enrolled into this study. The expression of PCNA, EGF and VEGF were detected by immunohistochemistry using SP methods. Results The positive rates of PCNA,EGF and VEGFin the control,CAG,IM and DYS increased gradually,and the rate of which in the IM were significantly higher than that in the control and CAG（ P 〉 0.05 ）. The positive rates of PCNALI in DYS were higher than that in IM（ P 〈 0.05）. Conclusion The increasing expression of PCNA, EGF and VEGF in IM and DYS may play important role in promoting carcinogenesis by affecting cell proliferation, and this characteristics can be of important value in diagnosis and treatment.

关 键 词：慢性萎缩性胃炎 增殖细胞核抗原 表皮生长因子 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤] R446.5[医药卫生—临床医学]