表观遗传与microRNA相互调控机制以及在抗肿瘤领域内的应用  

The Reciprocal Modulation Between Epigenetic and microRNA and The Application for Treatment of Malignant Tumors

作　　者：徐艳敏[1] 郭艳合[1] 刘立[1] 蔡荣[1] 钱程[1] 

机构地区：[1]浙江理工大学生命科学学院,杭州310018

出　　处：《生物化学与生物物理进展》2008年第12期1343-1350,共8页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展计划(973)(2004CB518804);国家高技术发展计划(863)(2006AA02Z126)资助项目;浙江省科技厅重点项目(2006C23006)~~

摘　　要：DNA甲基化和组蛋白修饰等表观遗传机制是恶性肿瘤发生发展的重要原因之一.然而近年来研究发现,microRNA表达水平改变也参与恶性肿瘤的形成.最新研究资料揭示,表观遗传可调控microRNA表达,而一些种类的microRNA也可调节表观遗传,并且二者之间相互作用可调控组织细胞内基因表达以及诱导体内恶性肿瘤产生.研究资料还显示,表观遗传主要通过DNA甲基化、组蛋白修饰等方式调控microRNA表达,而microRNA则通过调节DNA甲基化转移酶、维持细胞中DNA甲基化水平或改变组蛋白修饰等途径调控表观遗传.对microRNA与表观遗传之间的调控关系以及在抗肿瘤领域内的应用进行全面而系统的论述.The recent investigations have demonstrated that epigenetic such as DNA methylation and histone modification was closely associated with cell growth and malignant tumors, and epigenetic modification was responsible for an important cause of oncogenesis. However, for the recent years some observations have been also shown that the development of tumorigenesis was attributed to transformation expression in microRNA. The latest investigations have revealed that epigenetic was involved in modulation of microRNA expression, on the contrary some kinds of microRNAs could also control epigenetic, moreover, the reciprocal modulation between microRNA and epigenetic could regulate gene expression and induce tumorigenesis. At the same time the data likewise displayed that epigenetic adjusted microRNA expression principally in a way of DNA methylation or histone modification, nevertheless microRNA regulated epigenetic by way of methyltransferases expression, DNA methylation maintenance and histone modification. With regard to the reciprocal modulation between microRNA and epigenetic, a comprehensive and systemic review of reciprocal relationship in modulation of cell growth and oncogenesis was gived.

关 键 词：MIRNA 表观遗传 肿瘤发生 

分 类 号：R730.5[医药卫生—肿瘤]