大麻素(WIN55,212-2)对高眼压家兔模型降眼压作用的研究  

Effect of WIN55,212-2 on lowing rabbit IOP

作　　者：刘慧峰[1] 王万辉[1] 赵俊华[1] 

机构地区：[1]山西医科大学第二附属医院眼科,太原030001

出　　处：《眼科研究》2008年第12期929-931,共3页Chinese Ophthalmic Research

摘　　要：目的评价大麻素(WIN55,212-2)滴眼液在卡波姆诱导的兔慢性高眼压模型中的降压作用。方法人工诱导兔慢性高眼压模型。取右眼高眼压兔24只,随机分为A、B、C3个组,每组8只。右眼结膜囊内分别滴入0.125%大麻素滴眼液、0.5%噻吗心胺滴眼液及生理盐水,用药后每日测眼压1次。任选8只左眼为D组作空白对照。结果用药1周后眼压大麻素组为用药前的69%,噻吗心胺组为78%;用药3周后眼压大麻素组为用药前的45%,噻吗心胺组为60%。各组间最大降眼压幅度差异有统计学意义(P<0.01)。结论0.125%大麻素滴眼液点眼降眼压作用确定,与0.5%噻吗心胺比较,持续时间长,下降幅度大。Objective Glaucoma is one of causes of blindness clinically with the damage of optic papillary and retinal never fiber layers and glaueomatous visual field loss. To reduce the intraocular pressure（IOP） is a main purpose of management of glaucoma. The aim of this paper was to assess the effect of WIN55,212-2 on IOP in rabbit with earbomer-induced chronic elevation of IOP. Methods Experimental ocular hypertension model was induced in 24 right eyes of 24 rabbits by the anterior chamber injection of complex carbomer. 24 left eyes were in blank control group. 0.9% NS,0.5% timolol and 0. 125% WIN55, 212-2 ophthalmic drops was used topically 1 week after injection respectively in 3 number-matched groups. IOP was detected once per day after administration of the ophthalmic formulations for 3 weeks. Results The IOP was（34.3 ± 2.6） mmHg in timolol group,（34.6 ± 3.1 ）mmHg in WIN55,212-2 group and（34.1 ± 2.5）mmHg in NS group, showing a significant increase in comparison with blank control group（ 15.4 ± 3.9 ） mmHg （ P 〈 0. 05 ）. IOP reduced rapidly to 65 % in WIN55,212-2 group and 78% in timolol group 1 weeks after utilize of drugs, and decreased to 45% and 60% respectively in WIN55,212-2 group and timolol group 3 weeks after administration of drugs. The maximum reduction of IOP was significantly different among the groups（ P 〈0.01）. Conclusion These results indicate that WIN55, 212-2 solution has a in longer action duration and good effectiveness in lowering IOP.

关 键 词：眼压 大麻素(WIN55 212-2) 噻吗心胺 

分 类 号：R775[医药卫生—眼科]