综合干预对慢性乙型重型肝炎医院感染的影响  

The Efficacy of Synthesis Intervention to Nosocomial Infection in Patients with Severe Viral Hepatitis B.

作　　者：林玉英[1] 林国贤[1] 黄庆华[1] 郭伯棋[1] 邱荣仙[1] 

机构地区：[1]莆田学院附属医院,福建莆田351100

出　　处：《川北医学院学报》2008年第6期600-602,共3页Journal of North Sichuan Medical College

摘　　要：目的了解胸腺肽a1、双歧杆菌、诺氟沙星综合干预对慢性乙型重型肝炎医院感染的影响。方法对2002年8月至2006年12月我院入院的250例重型乙型肝炎,根据是否干预医院感染随机分为对照组120例、治疗组130例。统计分析和总结两组医院感染情况。结果对照组、治疗组医院感染率和感染例次率分别为43.33%(52/120)、25.38%(33/130)和55%(66/120)、30.77%(40/130),治疗组医院感染率和感染例次率显著降低(p<0.05)。两组感染部位均以腹腔为主,对照组和治疗组原发性腹膜炎发生率为30.83%(37/120)和19.23%(25/130),大肠埃希菌感染率分别为9.17%(11/120)和3.08%(4/130),肺炎克雷伯菌感染率分别为6.67%(8/120)和2.31%(3/130),两组差异显著(p<0.05)。结论胸腺肽a1、双歧杆菌、诺氟沙星综合干预可降低慢性乙型重症肝炎医院感染率,减少原发性腹膜炎,大肠埃希菌,肺炎克雷伯菌感染率。Objective To study the efficacy of synthesis intervention to nosocomial infection in patients with severe viral hepatitis B by the thymosin a1 ,the live combined bffidobaeterium and the norfloxacin capsules. Methods There were 250 cases of viral hepatitis in our hospital between August 2002 and December 2006. Those cases were divided into two groups by random. 130 cases of study group received prophylactic antibiotics therapy. 120 cases of control group did not received prophylactic antibiotics therapy. We analyzed the nosocomial infection. Results The infection rate and frequency rate in the control group was 43.33% （52/120） and frequency rate was 55% （66/120） while the study group was 25.38% （33/130） and frequency rate was 30.77% （40/130）. The ratios of infection and frequency infection showed that the study group was lower than that in control （p 〈 0. 05 ）. The occurring time of nosoeomial infection was significantly later （p 〈 0.01 ）. The most common infected sites were abdomen in two groups. The rate of spontaneous bacterial peritonitis （SBP） in the control group was 30.83% （37/120） while the study group was 19.23% （25/130）. The rates of Eseherichia coli （E. coli） were 9.17% （11/120） and 3.08% （4/130）. The rates of Klebsiella pneumonia were 6.6 7% （8/120） and 2.31% （3/130）. Two groups have significant difference （p 〈 0. 05 ）. Conclusion The thymosin a1 ,the live combined bifidobactefium and the norfloxacin capsules of synthesis intervention can not only drop nosoeomial infection rate and frequency rate but also decrease the incidence of SBP, E. coli and Klebsiella pneumonia infection.

关 键 词：医院感染 重型肝炎 预防 

分 类 号：R575.1[医药卫生—消化系统]