锥颅穿刺引流术对脑出血患者血清NSE水平的影响  

The Effect of Aspiration of Hematoma on the Serum Neuron-specific Enolase Concentration in Patients with Intracerebral Hemorrhage and Clinical Meaning

作　　者：宋伟健[1] 胡深[1] 颜杰浩[1] 唐映[1] 

机构地区：[1]广东医学院附属深圳南山人民医院,518052

出　　处：《医学研究杂志》2008年第12期73-75,共3页Journal of Medical Research

摘　　要：目的探讨锥颅穿刺引流术对脑出血患者血清神经元特异性烯醇化酶(NSE)水平的影响及临床意义。方法选择出血量30～50ml的脑出血患者45例,分为手术组23例和保守组22例。对照组18例为同期健康体检者。用ELISA法动态测定血清中神经元特异性烯醇化酶(NSE)的水平。结果①保守组患者NSE浓度在发病21天内高于对照组(P<0.01);②手术组患者NSE浓度在发病14天内高于对照组(P<0.01),21天时与对照组比较无显著性差异(P>0.05);③手术组患者NSE浓度在发病7天内与保守组比较无显著性差异(P>0.05),但在14天和21天时明显低于保守组(P<0.01)。结论锥颅穿刺引流术可以减轻脑出血患者的脑损伤。Objective To explore the effect of aspiration of hematoma on the serum neuron - specific enolase （NSE） concentration in patients with hypertensive intracerebral hemorrhage and its clinical meaning. Methods 45 cases of intracerebral hemorrhage with hematoma volumes of 30ml to 50ml were selected and divided into operative group （23 cases） and conservative group（22cases）. The control group （ 18 cases） were healthy. Serum NSE was detected with ELISA method. Results （1）The concentration of NSE in conservative group was obviously higher than that in control group within 21 days（ P 〈 0. 01 ）. （2）The concentration of NSE in operative group was higher than that in control group with in 14 days（ P 〈 0.01 ） ,but were no significant difference in 21days（ P 〉 0.05）. （3）The concentration of NSE in operative group was no significant difference than that in conservative group with in 7 days,but decreaced rapidly and was obviously lower than that in conservative group respectively in 14 days and 21 days（P 〈 0.01 ）. Conclusion The aspiration can reduce brain damage in the treatment of intracerebral hemorrhage.

关 键 词：脑出血 神经元特异性烯醇化酶 锥颅穿刺引流术 脑损伤 

分 类 号：R734.204[医药卫生—肿瘤] R742.7[医药卫生—临床医学]