EGFR基因在不同胃黏膜中表达的研究  

Expression of EGFR Gene in Various Gastric Mucosas and Gastric Cancer

作　　者：宋建忠[1] 苏秉忠[1] 刘彦琦[1] 

机构地区：[1]内蒙古医学院附属医院消化科,内蒙古呼和浩特010050

出　　处：《内蒙古医学杂志》2008年第11期1299-1301,F0003,共4页Inner Mongolia Medical Journal

摘　　要：目的:研究胃癌(gastric cancer,GC)及不同胃黏膜组织中表皮生长受体(EGFR)的表达规律及其与凋亡的关系,探讨胃癌形成过程中的可能机制,为临床应用以表皮生长受体靶点的胃癌防治措施提供理论依据。方法:采用免疫组织化学染色(SP法)检测不同胃黏膜组织中EGFR。30例浅表性胃炎(chronic super-ficial gastritis,CSG);31例萎缩性胃炎(chronic Atrophic gastritis,CAG),15例异型增生(Dysplasia,Dys),胃癌组织32例。结果:从CSG→CAG→Dys→GC过程中,EGFR表达均呈递增趋势。CSG灰度值(57.64±4.44)、CAG灰度值(55.05±6.97)、Dys灰度值(48.59±4.16);GC灰度值(32.25±4.13)。EGFR表达在CSG、CAG、Dys、GC之间表达有统计学意义(P<0.05)。胃癌组织EGFR的表达与年龄、性别、肿瘤大小无关;在临床分期和组织分化程度方面EGFR阳性表达率明显不同,具有统计学意义(P<0.05)。结论:EGFR基因表达可作为在胃黏膜由浅表向萎缩、不典型增生和胃癌发展过程中的有用指标,且EGFR基因表达可判断胃癌的组织类型,分化程度。Objective： To investigate the expression of EGFR in gastric cancer（GC）and various gastric mucosas and explore the possible roles of gastric mucous in the genesis of GC, for provide evidences for the prevention and cure of GC base on EGFR. Methods： The expression of EGFR in various gastric mucosas was detected by immunohistochemistry methods（sp - methods）. Result： In CSG, CAG, Dys and GC groups, the expression of EGFR was increasing. The value of gray scale was（57.64±4.44） in CSG group, （55.05±6.97） in CAG group, （48.59 ± 4.16） in Dys group, （32.25 ± 4.13） in CA2 group, The expression of EGFR showed difference among CSG, CAG, Dys and GC group（P 〈 0.05）, which was no related to age, sex, size of tumor, which was related to clinical staging and the degrees of differentiation. Conclusion： The expression of EGFR gene may be valuabie index for predicting the development of gastric mucosal lesions from superficial lesion to atrophy, atypical hyperplasia and GC.

关 键 词：EGFR基因 胃黏膜 胃癌 

分 类 号：R573.1[医药卫生—消化系统]