清化消瘀方对代谢综合征患者PPARγ、Leptin、TNF-α表达的干预研究  

Study of the Effects of Qinghuaxiaoyu Decoction on PPARγ,Leptin,TNF-αof Metabolic Syndromes

作　　者：何泮 曾庆明 廖蔚茜 景光光 张炜宁 

机构地区：[1]广东省深圳市罗湖区中医院,深圳518001 [2]广东省深圳市福田区中医院,深圳518049

出　　处：《中国中医急症》2008年第12期1691-1692,1698,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：广东省深圳市科技局科技计划项目（No.JH200505260240A）

摘　　要：目的观察清化消瘀方对代谢综合征患者过氧化物酶体增殖物激活受体亚型γ(PPARγ)、瘦素(Leptin)、肿瘤坏死因子(TNF-α)表达的影响。方法将60例患者随机分为两组,均予西医常规治疗,治疗组加用清化消瘀中药;提取治疗前后人体腹部皮下脂肪组织,制片,免疫组化法检测PPARγ、Leptin、TNF-α。结果两组均能够促进PPARγ的表达,下调Leptin、TNF-α,治疗组在促进PPARγ的表达,下调Leptin、TNF-α的表达方面均优于对照组。结论清化消瘀方通过干预代谢综合征患者PPARγ、Leptin、TNF-α的表达以改善胰岛素抵抗,为治疗代谢综合征的有效中药复方。ObJective： To observe the effects of Qinghuaxiaoyu Decoction on PPARγ Leptin, TNF - α of metabolic syndromes（MS）. Methods： 60 cases of patients were divided randomly into 2 groups：control group（ n = 30, treated with metformin hydrochioride tablets） ,treatment group（ n = 30, treated with metformin hydrochioride tablets and Qinghuaxiaoyu Decoction）. PPARγ, Leptin, TNF - α were stained by immunohistochemistry. Results： The PPARγ was increased and Leptin, TNF- α were decreased in both groups, and treatment group was better than control group. Conclusions： Qinghuaxiaoyu Decoction has steady and tried effect on MS. The possible mechanism is increasing PPARγ, and decreasing Leptin, TNF - α.

关 键 词：代谢综合征 PPARΓ LEPTIN TNF-Α 清化消瘀方 

分 类 号：R589[医药卫生—内分泌]