细胞黏附分子CD44变异体V6和上皮性钙黏附素在膀胱移行细胞癌中的表达及临床意义  

Expressions of CD44V6 and E-cad in bladder transitional cell carcinoma and their clinical significance

作　　者：葛波[1] 杨燕伟[1] 王宇光[1] 周英琼[1] 高漓[1] 

机构地区：[1]桂林医学院附属医院泌尿外科,广西桂林541001

出　　处：《第四军医大学学报》2008年第23期2177-2179,共3页Journal of the Fourth Military Medical University

基　　金：广西自然科学基金(0249018)

摘　　要：目的:探讨细胞黏附分子CD44的变异体V6(CD44V6)和上皮性钙黏附素(E-cad)在膀胱移行细胞癌(BTCC)中的表达及其临床意义.方法:应用SP免疫组化染色法检测87例膀胱移行细胞癌组织和10例正常组织中CD44V6和E-cad的表达.结果:正常膀胱黏膜CD44v6,E-cad均呈正常表达,细胞膜为黄褐色.87例膀胱癌组织中,CD44V6正常表达55.2%(48/87)、E-cad正常表达63.2%(55/87).CD44V6和E-cad在膀胱移行细胞癌组织中的表达与肿瘤的病理分级、临床分期及复发显著相关(P<0.05).结论:CD44V6和E-cad阳性表达率与膀胱移行细胞癌的生物学特性密切相关,其表达率降低表明肿瘤恶性程度增强.AIM： To investigate the expressions of CD44V6 and E-cad in bladder transitional cell carcinoma （ BTCC ） tissue and their clinical significance. METHODS： The expressions of CD44V6 and E-cad in 87 BTCC cases and 10 cases of normal tissue were determined by streptavidin-peroxidase immunohistochemical method. RESULTS： Proteins of CD44V6 and E-cad showed strongly positive expression in the normal bladder tissue. Positive rates of CD44V6 and E-cad were 55.2% （48/87） and 63.2% （ 55/87 ） respectively in 87 cases of bladder transitional cell cancer. The expressions of CIM4V6 and E-cad in BTCC had significant relations with the pathological grade, clinical stage and recurrence（P 〈0.05 ） ,and a positive relation was observed between the expressions of CD4V6 and E-cad in the BTCC. CONCLUSION： The expressions of CD44V6 and E-cad are significantly related to the biological behavior of BTCC, and the low expressions indicate the high malignance.

关 键 词：膀胱肿瘤 癌 移行细胞 CD44V6 钙黏附分子 

分 类 号：R737.14[医药卫生—肿瘤]