野菊花挥发油的提取及其β-环糊精包合物制备工艺研究  

Extraction of Volatile Oil from Chrysanthemum indicum and Preparation Techniques of Its β-cyclodextrin Inclusion Compound

作　　者：陈秋实[1,2] 张洪[1] 翁涛[2] 杨明丽[2] 

机构地区：[1]武汉大学药学院,武汉市430072 [2]武汉生物工程学院制药工程系,武汉市430415

出　　处：《中国药房》2008年第36期2820-2822,共3页China Pharmacy

摘　　要：目的:优选野菊花挥发油的最佳提取条件及其β-环糊精(β-CD)包合工艺。方法:以浸泡时间、超声波处理时间、提取时间、加水量为影响因素,以挥发油得率为指标优选提取工艺;以β-CD和野菊花挥发油投料比、包合时间、包合温度为影响因素,以包合物收率和挥发油包合率的综合评分为指标,优选包合工艺。结果:最佳提取条件为浸泡1.5h,超声波处理40min,加热提取6h,加水600mL。最佳包合条件为β-CD和野菊花挥发油投料比为8∶1,包合时间为2h,包合温度为40℃。结论:本试验方法的提取率较高,可得到稳定的包合物。OBJECTIVE： To optimize the extraction conditions of volatile oil from Chrysanthemum indicum and the processing techniques of its β- yclodextrin（β- CD） inclusion compound.METHODS：The extraction conditions of volatile oil from Chrysanthemum indicum was optimized taking soaking time, ultrasonic treatment time, water amount as influencing factors and with the yield of the volatile oil as index.The processing techniques of the β- yclodextrin （β CD） inclusion compound was optimized taking the ratio of β - CD to volatile oil, the time and temperature of the inclusion process as indexes and with the yield of the inclusion compound and the inclusion rate of the volatile oil as indexes. RESULTS： The optimal process for oil extraction was as follows：the soaking time = 1.5 h, the ultrasonic treatment time = 40 min, heating time = 6 h,water amount = 600 mL.The optimal processing conditions for（β- CD） inclusion compound of Chrysanthemum indicum were as follows： the ratio of β- CD to volatile oil = 8 ： 1, the inclusion time of the compound was 2 hours at 40 ℃. CONCLUSION：High extraction yield of vlatile oil and stable inclusion compound were obtained from the above method.

关 键 词：野菊花 挥发油 正交试验 提取工艺 Β-环糊精 

分 类 号：R284.2[医药卫生—中药学] R943[医药卫生—中医学]