A型肉毒毒素缓解脑瘫儿童小腿三头肌痉挛最佳剂量研究  

Optimal Dose of Botulinum Toxin A to Release Spasticity of Triceps Surae in Children with Cerebral Palsy

作　　者：刘建军[1,2] 纪树荣[1,2] 胡莹媛[1,2] 吴卫红[1,2] 李燕春[1,2] 陆华宝[1,2] 张雁[1,2] 

机构地区：[1]首都医科大学康复医学院,北京市100068 [2]中国康复研究中心北京博爱医院,北京市100068

出　　处：《中国康复理论与实践》2008年第12期1173-1176,共4页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的确定治疗脑瘫痉挛的理想A型肉毒毒素(BTX-A)剂量计算公式中的系数。方法将58例脑瘫患儿(男性38例、女性20例,年龄27～144个月,平均59.3±24.6个月)按剂量系数分为A、B、C、D、E五组,给予不同剂量的BTX-A治疗。结果从运动功能改善的角度考虑,D组的BTX-A剂量比较适合;从疗效持续时间的角度考虑,C组的BTX-A剂量比较适合,理想的系数应为1.8。结论小腿三头肌初次BTX-A理想剂量的计算公式应为:剂量(I U)=(1+1.8×MAS评分)×体重(kg)。Objective To determine the coefficient in the formula of the optimal dose of botulinum toxin A （BTX-A） to treat spastic cerebral palsy （CP）. Methods 58 CP children （male 38, female 20, mean age 59.3±24.6 months, range 27 to 144 months） wer divided into A, B, C, D and E five groups according to used coefficient and treated by BTX-A with different doses to release th spasticity. Results According to the improvement of motor function, the BTX-A dose of the group D was optimal. According to th effective endurance, the BTX-A dose of the group C was optimal. The optimal coefficient was 1.8. Conclusion The formula of th optimal BTX-A dose injected in triceps surae is dose = （1 ＋ 1.8 ）〈 MAS score）× body weight.

关 键 词：脑性瘫痪 痉挛 A型肉毒毒素 神经阻滞 剂量 

分 类 号：R742.3[医药卫生—神经病学与精神病学]