δ氨基酮戊酸光动力法治疗颜面部原发性皮肤癌  

Treatment of primary carcinomas of facial skin by photodynamic therapy with topical δ-aminolaevulinic acid

作　　者：夏育民[1] 徐世正[1] 刘美玲[1] 梁虹[1] 何萍[1] 江珊[1] 

机构地区：[1]武汉大学人民医院皮肤科,武汉430060

出　　处：《中华医学美学美容杂志》2008年第5期309-311,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的探讨δ氨基酮戊酸光动力学疗法（δ-aminolae vulinic acid-photodynamic therapy，ALA—PDT）治疗颜面部原发性皮肤癌的疗效。方法对14例鳞状细胞癌（squamous cell carcinoma，SCC）、38例基底细胞癌（basal cell carcinoma，BCC）、5例Bowen病患者进行ALA-PDT治疗，依据肿瘤部位及形态大小，每位患者分别接受治疗4～8次。结果57例患者接受治疗后，分别有10例（71．4％）SCC、34例（89．5％）BCC及5例（100％）Bowen病患者获得治愈，其余患者病情皆示显效。治疗结束后，肿瘤周边正常组织基本得以保留，无瘢痕形成。末次治疗结束6个月时，上述SCC、BCC及Bowen病痊愈患者分别有1例（10．0％）、4例（11．8％）及0例（0％）复发。结论ALA—PDT适用于颜面部位的局限性、原发性皮肤癌的治疗，是一种疗效好、副作用少且对容貌损害较轻的新疗法。Objective To evaluate the effects of δ-aminolaevulinic acid-photodynamic therapy （ALA-PDT） in the treatment of primary carcinomas on the facial skin. Methods In the accordance of these tumors＇ sites and morphology, 14 patients with squamous cell carcinoma （SCC）, 38 patients with basal cell carcinoma （BCC） and 5 patients with Bowen disease were given four to eight times of topical ALA followed by PDT. Results Ten （71.4 %） SCC cases, 34 （89.5 %） BCC cases and all （100 %） Bowen disease cases completely recovered after ALA-PDT. The others all obtained significant improvement after final treatment. Their unaffected tissues around these tumors kept well and no scaring appeared after ALA-PDT. The recurrence rates among the completely-recovered cases were 10.0 % （SCC）, 11.8 %（BCC） and 0 %（Bowen disease）, respectively, by the end of six-month＇s follow-up. Conclusions Topical ALA-PDT is an effective new therapeutical method with lower recurrence rates, fewer side effects, no scar formation and excellent cosmetic results for primary carcinomas localizing on the facial skin.

关 键 词：δ氨基酮戊酸 光动力学疗法 鳞状细胞癌 基底细胞癌 BOWEN病 

分 类 号：R739.5[医药卫生—肿瘤]