学龄高功能孤独障碍患儿脑灰质体积的对照观察  

Measurement of grey matter volume changes in school aged children with high functioning autism

作　　者：杭跃跃[1] 柯晓燕[1,2] 洪珊珊[2] 李惠国[1] 汤天宇[2] 邹冰[1] 周振宇[2] 阮宗才[2] 陆祖宏[2] 

机构地区：[1]南京医科大学附属脑科医院儿童心理卫生研究中心,江苏南京210029 [2]东南大学儿童发展与学习科学,教育部重点实验室,江苏南京210096

出　　处：《中国医学影像技术》2008年第12期1913-1915,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金面上项目(30570655);南京市医学重点科技发展项目(ZKX06025);南京市科技发展计划(200701109)

摘　　要：目的比较学龄高功能孤独障碍儿童与正常儿童脑灰质体积的差异。方法在SPM5平台上使用VOI tool工具箱测量并比较18名年龄6～14岁的孤独障碍患儿和16名相匹配的正常儿童的全脑体积、灰质体积及左右额叶、顶叶、颞叶、枕叶的灰质体积。结果孤独障碍组与正常对照组相比全脑体积差异无统计学意义(P>0.05),孤独障碍组与正常对照组相比左侧顶叶和右侧枕叶灰质体积增大,差异有统计学意义(P<0.05)。结论学龄高功能孤独障碍患儿中存在脑灰质体积的异常。Objective To assess the grey matter volume changes in school aged children with high functional autism using three-dimentional magnetic resonance imaging.Methods The total brain volume,total white matter,total grey matter,right and left grey matter of frontal,temporal,parietal and occipital lobe were measured in 18 autistic disorder children（6-14 years old）and 16 matched controls using VOI tool box based on SPM5.Results No significant difference was found in total brain volume between autistic disorder group and control group（P〉0.05）.Compared with the control group,the grey matter volume in autistic disorder patients group significantly increased in the left parietal lobe and right occipital lobe（P〈0.05）.Conclusion The volume of grey matter is obviously abnormal in school aged children with high functioning autism.

关 键 词：孤独性障碍 磁共振成像 脑灰质 

分 类 号：R749.94[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]