Peripheral and mesenteric serum levels of CEA and cytokeratins,staging and histopathological variables in colorectal adenocarcinoma  被引量:4

Peripheral and mesenteric serum levels of CEA and cytokeratins,staging and histopathological variables in colorectal adenocarcinoma

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作  者:Ivan Gregório Ivankovics Luis César Fernandes Sarhan Sydeney Saad Delcio Matos 

机构地区:[1]Coloproctology Group,Discipline of Surgical Gastroenterology,Department of Surgery,Federal University of So Paulo-Escola Paulista de Medicina,So Paulo-SP,04005-004,Brazil

出  处:《World Journal of Gastroenterology》2008年第43期6699-6703,共5页世界胃肠病学杂志(英文版)

摘  要:AIM: To evaluate the differences that exist bet- ween peripheral and mesenteric serum levels of carcinoembryonic antigen (CEA) and cytokeratins in patients with colorectal adenocarcinoma. METHODS: One hundred and thirty-eight patients with colorectal adenocarcinoma who underwent surgery at Hospital Sao Paulo (Discipline of Surgical Gastroenterology of UNIFESP-EPM) between December 1993 and March 2000 were retrospectively analyzed. Differences between CEA and cytokeratin (TPA-M) levels in peripheral blood (P) and in mesenteric blood (M) were studied. Associations were investigated between peripheral and mesenteric levels and the staging and histopathological variables (degree of cell differentiation, macroscopic appearance, tumor dimensions and presence of lymphatic and venous invasion). RESULTS: Differences were observed in the numerical values of the marker levels: CEA (M) (39.10 mg/1 ± 121.19 mg/L) vs CEA (P) (38.5 mg/L ± 122.55 mg/L), P 〈 0.05; TPA-M (M) (325.06 U/L ±527.29 U/L) vs TPA-M (P) (279.48 U/L ±455.81 U/L), P 〈 0.01. The mesenteric CEA levels were higher in more advanced tumors (P 〈 0.01), in vegetating lesions (34.44 mg/L ± 93.07 mg/L) (P 〈 0.01) and with venous invasion (48.41 mg/L ± 129.86 mg/L) (P 〈 0.05). Peripheral CEA was higher with more advanced staging (P 〈 0.01)and in lesions with venous invasion (53.23 mg/L ± 258.57 mg/L) (P 〈 0.05). The patients demonstrated increased mesenteric and peripheral TPA-M levels with more advanced tumors (P 〈 0.01 and P 〈 0.01) and in non-ulcerated lesions [530.45 U/L =1= 997.46 U/L (P 〈 0.05) and 457.95 U/L ± 811.36 U/L (P 〈 0.01)]. CONCLUSION: The mesenteric levels of the tumor markers CEA and cytokeratins were higher than the peripheral levels in these colorectal adenocarcinoma patients, Higher levels of these biologic tumor markers are associated with an advanced state of cancerous dissemination瞄准:为了评估在外设和 mes 伤寒浆液之间存在的差别,与颜色在病人 carcinoembryonic 铺平抗原(CEA ) 和 cytokeratins 表面的腺癌。方法:有颜色的 138 个病人表面的腺癌在在 1993 年 12 月和 2000 年 3 月之间的医院 Sao Paulo (UNIFESP-EPM 的外科的肠胃病学的纪律) 经历了外科的人,回顾地被分析。CEA 和 cytokeratin (TPA-M ) 之间的差别在外部血(P) 并且在 mes 伤寒血(M) 的层次被学习。协会在外设和 mes 伤寒层次和阶段和组织病理学说的变量(细胞分化,宏观的外观,肿瘤尺寸和淋巴、静脉的侵略的存在的度) 之间被调查。结果:差别在标记层次的数字价值被观察:CEA (M)(39.10 mg/L +/- 121.19 mg/L ) 对 CEA (P)(38.5 mg/L +/- 122.55 mg/L ) , P < 0.05;TPA-M (M)(325.06 U/L +/- 527.29 U/L ) 对 TPA-M (P)(279.48 U/L +/- 455.81 U/L ) , P < 0.01。mes 伤寒 CEA 层次在更先进的肿瘤是更高的(P < 0.01 ) ,在生长损害(34.44 mg/L +/- 93.07 mg/L )(P < 0.01 ) 并且与静脉的侵略(48.41 mg/L +/- 129.86 mg/L )(P < 0.05 ) 。外部 CEA 与更先进的阶段是更高的(P < 0.01 ) 并且在有静脉的侵略的损害(53.23 mg/L +/- 158.57 mg/L )(P < 0.05 ) 。病人表明了有更多的 TPA-M 层次预付肿瘤的伤寒、外部的增加的 mes (P < 0.01 并且 P < 0.01 ) 并且在非溃烂的损害[530.45 U/L +/- 997.46 U/L (P < 0.05 ) 并且 457.95 U/L +/- 811.36 U/L (P < 0.01 )] 。结论:肿瘤标记 CEA 和 cytokeratins 的 mes 伤寒层次比在这些的外部层次渲染表面的腺癌病人高。这些生物学的肿瘤标记的高水平与癌的传播的一个先进状态被联系。

关 键 词:Colonic neoplasms Rectal neoplasms Biological tumor markers Carcinoembryonic antigen CYTOKERATINS 

分 类 号:R735.3[医药卫生—肿瘤]

 

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