原发性肝癌血清巨噬细胞移动抑制因子和血管内皮生长因子水平  

Expressions of MIF and VEGF in patients with hepaticellular carcinomn

作　　者：徐天敏[1] 卫峥[1] 张建中[1] 黄和冲[1] 王永忠[1] 

机构地区：[1]常州市第三人民医院感染病科,213001

出　　处：《江苏医药》2008年第12期1203-1204,共2页Jiangsu Medical Journal

摘　　要：目的探讨原发性肝癌(PHC)患者血清巨噬细胞移动抑制因子(MIF)与血管内皮生长因子(VEGF)的表达。方法79例PHC经CT或B超引导下肝脏穿刺病理组织学检查证实,用ELISA法测定血清中MIF和VEGF水平。结果PHC组血清中MIF和VEGF浓度分别为(56.2±18.1)ng/ml和(531.9±102.7)pg/ml,明显高于正常对照组的(29.6±12.3)ng/ml和(223.2±72.6)pg/ml(P<0.01);在PHC组中Ⅰ期、Ⅱ期和Ⅲ期MIF浓度分别为(54.8±11.2)ng/ml、(81.1±28.5)ng/ml和(97.6±25.6)ng/ml;VEGF浓度分别为(527.6±132.7)pg/ml、(546.5±107.4)pg/ml和(579.4±81.3)pg/ml;组间比较亦有明显差异(P<0.05);PHC组中MIF与VEGF表达呈正相关(r=0.745)。结论MIF和VEGF参与了PHC细胞的生长和转移,可作为监测PHC进展、转移的指标之一。Objective To investigate the expressions of macrophage migration inhibitory factor（MIF） and vascular endothelial growth factor（VEGF） in patients with primary hepaticellular carcinomn（PHC）.Methods Enzyme-linked immunosorbent assays（ELISA） was used to detect the concenttrations of MIF and VEGF in serum samples of 79 patients with PHC.Results The levels of serum MIF and VEGF in PHC patients were（56.2±18.1）ng/ml and（531.9±102.7）pg/ml,respectively,which were significantly higher than （29.6±12.3）ng/ml and（223.2±72.6）pg/ml in normal subjects（P〈0.01）.In PHC group,serum MIF level was（54.8±11.2）ng/ml in liver metastasis group,（81.1±28.5）ng/ml in lymph metastasis group and（97.6±25.6）ng/ml in serosa metastasis group,and,and serum VEGF levels were（527.6±132.7）pg/ml,（546.5±107.4）pg/ml and（579.4±81.3）pg/ml,respectively.The defferences were significant amoung the three groups（P〈0.05）.Conclusion MIF and VEGF may be involved in the growth and migration of cells.Detection of serum MIF and VEGF is valuable for predicting the progress and migration of PHC.

关 键 词：原发性肝癌 移动抑制因子 血管内皮生长因子 

分 类 号：R735[医药卫生—肿瘤]