淫羊藿药材HPLC指纹图谱的勾兑研究  

Blending of crude Epimedium Brevicornum according to their HPLC fingerprints

作　　者：王彬[1] 黄河舟[2] 朱臻宇[2] 张海[1] 纪松岗[3] 柴逸峰[2] 

机构地区：[1]东方肝胆外科医院药材科,上海200438 [2]第二军医大学药学院,上海200433 [3]中国人民解放军第401医院,山东青岛266071

出　　处：《药学实践杂志》2008年第6期432-434,456,共4页Journal of Pharmaceutical Practice

基　　金：国家"十一五"科技支撑计划课题(2006BAI08B03-07).

摘　　要：目的:在中药HPLC指纹图谱数据的基础上,对不同来源的中药淫羊藿原药材进行了勾兑研究,寻找提高药材指纹图谱相似度,稳定药材质量的新途径。方法:以道地药材为勾兑目标,药材的夹角余弦相似度为评价指标,使用系统优化的勾兑比例投料进行勾兑实验,采集勾兑药材的HPLC指纹图谱。结果:勾兑后,药材与道地药材的相似度评价结果明显提高,与理论计算的结果一致。结论:相似度差异较大的不同批次中药材通过基于中药指纹图谱的勾兑,相似度评价得到提高,为中药原药材的充分利用提供了新的参考方法。Objective ： To find a new way of improving the quality of TCM, blendings of crude Epimedium Brevicomum from various sources were studied according to their Fingerprints. Methods： Systematic optimization was adopted to determine the mixing ratio of different kinds of non-genuine crude drugs in order to maximize the similarity, which is based on the cosine value between the fingerprints of genuine and non-genuine crude drugs respectively. Fingerprints data were collected after the blending. Results ：The similarity of drugs was improved evidently, and it was in accordance with the calculation result. Conclusion：Quality improvement of TCM can be made by blending. Optimized blending of crude drugs might be an efficient method in making full use of the relatively inadequate TCM resources.

关 键 词：勾兑 中药材 淫羊藿 指纹图谱 

分 类 号：R284.1[医药卫生—中药学]