半红树植物阔苞菊茎叶的化学成分  

Chemical constituents from the stems and leaves of marine mangrove plant Pluchea indica(L.)Less.

作　　者：王健[1] 裴月湖[1] 林文翰[2] 邓志威[3] 乔莉[1] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016 [2]北京大学天然药物与仿生药物国家重点实验室,北京100083 [3]北京师范大学分析测试中心,北京100075

出　　处：《沈阳药科大学学报》2008年第12期960-963,共4页Journal of Shenyang Pharmaceutical University

基　　金：国家海洋863计划资助课题(2001AA620403,2002AA217081)

摘　　要：目的为寻找半红树植物阔苞菊[Pluchea indica(L.)Less.]不同于陆生植物的次生代谢产物及民间治疗瘰疬(淋巴腺结核)的物质基础,对其进行化学成分的研究。方法采用硅胶、SephadexLH-20、HPLC等色谱方法进行分离纯化,通过理化性质、波谱方法以及结合文献对照鉴定结构。结果从阔苞菊体积分数为90%的乙醇提取物的乙酸乙酯部分分离并鉴定了3个噻吩类衍生物及3个倍半萜类化合物,分别为:2-(1,3-戊二炔)-5-(4-乙酰氧基-3-羟基-1-丁炔)-噻吩[2-(pant-1,3-diynyl)-5-(4-acetoxy-3-hydroxybuta-1-ynyl)-thiophene,1]、2-(1,3-戊二炔)-5-(4-乙酰氧基-3-氯-1-丁炔)-噻吩[2-(pant-1,3-diynyl)-5-(4-acetoxy-3-chlorobuta-1-ynyl)-thio-phene,2]、2-(1,3-戊二炔)-5-(3、4-二羟基-1-丁炔)-噻吩[2-(pant-1,3-diynyl)-5-(3,4-dihydroxybuta-1-ynyl)-thiophene,3]、8,11-二羟基-1(10)-瓦伦烯[valenc-1(10)-ene-8,11-diol,4]、2,8,11-三羟基-1(10)-瓦伦烯[valenc-1(10)-ene-2,8,11-triol,5]、5-氧代-5,6-氢-希菲比尔醇[5-oxo-5,6-H-silphiperfolen,6]。结论化合物2-6均为首次从该种植物中获得。Objective To investigate the chemical constituents of the stems and leaves of Pluchea indica （L.） Less.. Methods The compounds were isolated by silica gel chromatography column in associating with Sephadex LH-20 and HPLC chromatography. Their structures were elucidated by spectroscopic analysis. Results Six compounds, including three sesquiterpenes and three thiopene derivatives, were obtained. Their structures were identified as 2-（ pant-1, 3-diynyl）-5-（ 4-acetoxy-3-hydroxybuta-1-ynyl）-thiophene （ 1 ）, 2- （pant-1, 3-diynyl）-5-（4-acetoxy-3-chlorobuta-1-ynyl）-thiophene（2）, 2- （pant-1, 3-diynyl）-5-（3, 4-dihydroxybuta- 1-ynyl） - thiophene （3）, valenc- 1 （ 10）-ene-8, 11-diol （4）, valenc- 1 （ 10 ）-ene-2, 8, 11- triol （ 5 ）, 1,2, 4, 8- tetramethyl-（4R, 7S, 8R, 11R ）-3-cyeloundecenone （6）. Conclusions Compounds 2 - 6 are isolated from Pluchea indica （L.） Less. for the first time.

关 键 词：红树植物 阔苞菊 化学成分 结构鉴定 

分 类 号：R914[医药卫生—药物化学]