Design,synthesis and antitumor activity of 3-substituted quinolone derivatives (Ⅰ)  

作　　者：Hua Wang Qi Dong You Zhi Yu Li Yi Quan Zou 

机构地区：[1]Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

出　　处：《Chinese Chemical Letters》2008年第12期1395-1397,共3页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China (No.30271543).

摘　　要：A series of quinolone derivatives containing benzimidazole, benzoxazole or benzothiazole ring were synthesized. The cytotoxicity of 12 new compounds was evaluated in KB, Be17402, A2780 and HT-29 cell lines. Most of synthesized compounds showed moderate inhibitory activity against cancer cells. The inhibitory activities of 6k, against KB and A2780 tumor ceils are comparable to that of topotecan, one of topoisomerase I inhibitors.A series of quinolone derivatives containing benzimidazole, benzoxazole or benzothiazole ring were synthesized. The cytotoxicity of 12 new compounds was evaluated in KB, Be17402, A2780 and HT-29 cell lines. Most of synthesized compounds showed moderate inhibitory activity against cancer cells. The inhibitory activities of 6k, against KB and A2780 tumor ceils are comparable to that of topotecan, one of topoisomerase I inhibitors.

关 键 词：Quinolone derivatives SYNTHESIS ANTITUMOR 

分 类 号：TQ46[化学工程—制药化工]