维生素D受体基因多态性与血铅水平的Meta分析  

META-ANALYSIS OF THE RELATIONSHIP OF VITAMINE D RECEPTOR GENOTYPE WITH THE BLOOD LEAD LEVEL

作　　者：闫娟[1] 杨跃林[2] 王培席[3] 

机构地区：[1]天津市医学科学技术信息研究所,天津300070 [2]四川大学华西第四医院 [3]河南大学公共卫生研究所

出　　处：《现代预防医学》2008年第24期4769-4770,共2页Modern Preventive Medicine

摘　　要：[目的]系统研究维生素D受体基因多态性与血铅水平的关系。[方法]通过数据库检索1990～2007年国内外生物医学期刊发表的有关铅与VDR基因多态性关联性研究的相关文献,用Meta分析软件Revman4.2进行分析。[结果]VDR-Bb/BB基因型的血铅水平高于VDR-bb基因型的血铅水平,有统计学意义(Z=2.66,P=0.008)。[结论]VDR基因型可能是导致铅易感的因素之一。[ Objective] To systemic study the relationship of vitamine D receptor gene with the blood lead level. [Methods] We searched literatures about VDR and blood lead in databases which published from 1990 to 2007, The Metaanalysis software, RevMan 4.2 was used to analyze published literatures related to the relationship of lead and polymorphism of VDR gene. [ Results] The blood lead level of VDR-Bb/BB genotype was significantly higher than that of VDR-bb genotype （Z =2.66, P = 0.008）. [Conclusion] The genotype of VDR may be one factor to induce the susceptible to lead.

关 键 词：维生素D受体 血铅 META分析 

分 类 号：R151.2[医药卫生—营养与食品卫生学]