Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System  

作　　者：于文利 夏菲 金鹤阳 林长春 赵亚平 蒋思源 何琳 

机构地区：[1]School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, China [2]Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China

出　　处：《Chinese Journal of Chemical Engineering》2008年第6期956-960,共5页中国化学工程学报（英文版）

基　　金：Supported by Shanghai Special Foundation on Nanomaterials(0243nm305);the National High Technology Research and Development Program of China(2007AA10Z350)

摘　　要：The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system （ASES） and characterized by scanning electronic microscope （SEM）, X-ray diffraction （XRD）, and Fourier transform infrared （FT-IR） analysis. The effects of operational parameters including pressure, temperature, solution concentration, and ratio of flow rate （CO2/solution, r） on particle size （PS）, yield, and morphology were investigated. The results showed that microparticles of β-sitosterol （less than 1000 nm size and larger than 70% yield） could be obtained at 10-15 MPa, 35 50℃, 15 mg·ml^-1, 10/1（r）; β-sitosterol particles were found to occur as three mophologies： flakes, rods, and spheres by varying ratio of flow rate or solution concentration. In contrast, the crystallinity of β-sitosterol decreased, whereas its molecular structure remained almost unchanged after being ASES-treated. Therefore, ASES was an effective method to produce submicroparticles of β-sitosterol.-sitosterol 的 submicroparticles 被使用一个喷雾器溶剂抽取系统(ASES ) 生产并且由扫描电子显微镜(SEM ) 描绘了， X 光检查衍射(XRD ) ，和 Fourier 转变红外线(英尺红外) 分析。包括流动的压力，温度，答案集中，和比率的运作的参数的效果评价(CO2/solution， r ) 在粒子上，尺寸(PS ) ，产量，和形态学被调查。结果显示出 -sitosterol 的那 microparticles (不到 1000 nm 尺寸并且比 70% 产量大) 能在 10-15 MPa 被获得， 3550 敢漠 ? 桴 ? 牧癡? 牴楡吗？

关 键 词：Β-SITOSTEROL submicroparticle aerosol solvent extraction system supercritical CO2 MICRONIZATION 

分 类 号：TQ413[化学工程]