出 处:《中国循证医学杂志》2008年第12期1105-1111,共7页Chinese Journal of Evidence-based Medicine
摘 要:目的检索和分析国内外肺癌领域发表文献情况,了解肺癌的研究现状和方向,为肺癌的循证研究和临床实践提供参考。方法在CBMdisc、PubMed、Cochrane图书馆和NGC指南数据库中检索所有肺癌方面的文献,按照文献的发表年限、研究对象、文献类型、主题分类等进行统计分析。结果①肺癌研究文献呈逐年稳步增长的趋势,国内增速明显高于国外。国内发表的高证据级别肺癌研究文献均相应晚于国外。②国内外肺癌研究以临床为主,主要研究内容为诊断。国内肺癌的基础研究和临床研究占肺癌总文献量的百分比均低于国外。③CBMdisc和PubMed中的肺癌文献主要为原始研究。国内临床指南、系统评价和Meta分析、随机对照试验、综述的数量远低于国外。CBMdisc、PubMed、Cochrane系统评价和NGC提供的高证据级别研究文献内容以治疗为主。④CBMdisc肺癌研究文献中出现频次最高的副主题词为病理学,PubMed为诊断,Cochrane图书馆为药物治疗。结论①肺癌的原始研究以临床为主,主要集中在预防、早期诊断和综合治疗方面。肺癌发病机制、分子水平的诊断和治疗技术是近年来研究的热点。肺癌规范化、标准化诊疗是肺癌研究的另一方向。肺癌的规范化、标准化治疗得到更多的关注,肺癌诊断的循证研究尚需加强。②我国需加强肺癌的预防和循证医学的研究。③选择有代表性的原始研究文献数据库和二次研究文献数据库,将循证医学证据级别分类引入文献定量分析中,实现肺癌文献不同特征的计量分析,可以分析肺癌的研究现状和方向。Objective To investigate the current status and focus of both domestic and international lung cancer research in order to provide information for evidence-based research and clinical treatment of lung cancer. Methods All publications about lung cancer were collected from CBMdisc, PubMed, The Cochrane Library, and NGC. Statistical analysis was performed according to the publication year, basic or clinical study, publication types and subjects. Results ① The publications concerning lung cancer grew steadily year by year. The annual growth rate of literature was higher in China than abroad. Compared with international research, the first literature with a high evidence level was published later in China. ② Most literature focused on clinical studies. The proportions of both basic studies and clinical studies of total literature were lower in China than those abroad. The clinical and basic research on lung cancer focused on diagnosis. ③ The major publication type in CBMdisc and PubMed was original study. The numbers of guidelines, systematic reviews, meta-analyses, and randomized controlled trials of lung cancer research were much lower than those abroad. Most literature of high evidence level addressed the treatment of lung cancer. ④The subheadings of the highest frequency in CBMdisc, PubMed, and CL were pathology, diagnosis, and medication, respectively. Conclusion The original studies of lung cancer mainly focus on the clinical aspect, including prevention, early diagnosis, and comprehensive treatment. In recent years, the focuses of lung cancer research include the pathogenesis, diagnosis, and treatment on the basis of molecular biology, as well as the standardized diagnosis and treatment of lung cancer. Evidence-based research on the diagnosis of lung cancer should be strengthened. Prevention and evidence-based research on lung cancer should be further improved in China. We may choose the representative literature databases and combine the evidence level classification method into bibliometric analysis,
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