肺癌中细胞黏附分子-1和L-选择素的表达及临床意义  

Expressions of intercellular adhesion molecule-1 and L-selection in lung carcinoma and their clinical significance

作　　者：陈连宏[1] 周勇安[1] 薛军辉[2] 姜涛[1] 钟代星[1] 

机构地区：[1]第四军医大学唐都医院胸外科,西安市710038 [2]第四军医大学航空航天医学系临床医学教研室,西安市710032

出　　处：《实用医学杂志》2008年第23期4049-4051,共3页The Journal of Practical Medicine

摘　　要：目的:检测细胞黏附分子-1(ICAM-1)和L-选择素水平,探讨其与肺癌发展、转移、治疗、预后之间的关系。方法:采用免疫组织化学法检测48例肺癌组织ICAM-1的表达,用酶联免疫吸附试验检测48例肺癌患者、18例肺良性病变患者及20例健康志愿者血ICAM-1和L-选择素的浓度。结果:(1)Ⅲ+Ⅳ期肺癌组织和有淋巴结转移者ICAM-1表达分别显著高于Ⅰ+Ⅱ期和无淋巴结转移者,腺癌组织中ICAM-1表达显著高于鳞癌。(2)肺癌和肺良性病变患者血中ICAM-1和L-选择素水平明显高于健康志愿者,肺癌与肺良性病变患者ICAM-1相比差异有显著性,而L-选择素差异无显著性。Ⅲ+Ⅳ期显著高于Ⅰ+Ⅱ期,有转移者与无转移者相比差异均有统计学意义。结论:组织ICAM-1与肺癌的发展和转移有关,检测血ICAM-1和L-选择素含量可以作为肺癌术前诊断及术后效果评估指标之一。Objective To investigate the roles of intercellular adhesion molecule-1 （ICAM-1） and L-selectin in the metastasis and progression of lung carcinoma. Methods ICAM- 1 expression was detected by immunohistochemistry in the cancer tissues from 48 patients with lung cancer and serum levels of ICAM-1 and L-selectin were measured using ELISA in 48 patients with lung cancer, 18 with benign lung diseases, and 20 healthy controls. Results ICAM-1 expression was significantly higher in the patients with Ⅲ to Ⅳ disease and lymph node metastasis than those with Ⅰ to Ⅱ disease but no lymph node involvement and it was higher in adenocarcinoma than in squamous cell carcinoma. Serum levels of ICAM-1 and L-selectin were markedly higher in the patients with lung cancer or benign diseases than in the controls while ICAM-1 level was significantly higher in the patients with lung cancer than in those with benign diseases. There were significant differences in levels of ICAM-1 and L-selectin between the patients with Ⅲ to Ⅳ disease or with metastasis and those with Ⅰto Ⅱdisease or with no metastasis. Conclusions ICAM-1 may be associated with the development and metastasis of lung cancer. Serum levels of ICAM-1 and L-selectin can be used as one of the indicators for preoperative diagnosis and postoperative evaluation of lung cancer.

关 键 词：肺肿瘤 L-选择素 免疫组织化学 酶联免疫吸附测定 细胞间黏附分子-1 

分 类 号：R734.2[医药卫生—肿瘤]