乙型肝炎肝硬化患者外周血骨桥蛋白与IL-18水平变化的临床意义  

Observing on relationship in changes of OPN,IL-18 levels with hepatic function in patients with chronic hepatic disease infected by HBV

作　　者：潘留兰[1] 周晓琦[1] 周玉华[1] 田月丽[1] 李东复[1] 

机构地区：[1]吉林大学第二医院消化内科,长春130041

出　　处：《中国免疫学杂志》2008年第12期1130-1132,共3页Chinese Journal of Immunology

基　　金：吉林省科技厅基金资助课题(2006416-4)

摘　　要：目的:探讨慢性乙型肝炎、肝硬化患者外周血细胞因子骨桥蛋白与IL-18水平变化的临床意义。方法:应用ELISA法对102例慢性乙型肝炎、34例乙型肝炎肝硬化、95例HBV携带者及20名健康献血者(对照组)外周血细胞因子骨桥蛋白与IL-18表达水平进行了测定。结果:慢性乙型肝炎、肝硬化患者组外周血骨桥蛋白及IL-18表达水平明显高于对照组(P<0.05);肝硬化患者组骨桥蛋白、IL-18水平明显高于慢性乙型肝炎组(P<0.05);慢性乙型肝炎重型组骨桥蛋白、IL-18水平明显高于慢性乙型肝炎轻型组(P<0.05);慢性乙型肝炎患者血清总胆红素水平与骨桥蛋白和IL-18表达水平呈正相关关系(r=0.71,P<0.05;r=0.78,P<0.05)。结论:乙肝病毒感染性慢性肝脏疾病发生发展与细胞因子骨桥蛋白及IL-18水平变化相关,慢性乙型肝炎、肝炎后肝硬化患者外周血骨桥蛋白与IL-18表达水平呈正相关关系(r=0.74,P<0.05)。Objective：To observe clinical significance between changes of OPN,IL-18 levels and relation ship with hepatic function in patients with chronic hepatic disease infected by HBV.Methods：The levels of OPN,IL-18 in peripheral blood of 102 patients with chronic hepatitis B,34 patients with hepatitis B-related cirrhosis,95 HBV carriers and 20 healthy people as the control group were respectively detected with ELISA.Results：The levels of OPN and IL-18 in chronic hepatitis B and hepatitis B-related cirrhosis groups were significantly increased compared with that of health control group（P〈0.05）;OPN and IL-18 in hepatitis B-related cirrhosis group were markedly higher than those of chronic hepatitis B group;OPN and IL-18 in mild type of hepatitis B were significantly higher than those of heavy group of chronic hepatitis B and there was positive relationship between the levels of OPN or IL-18 and the chronic liver disease degree（r=0.71,P〈0.05;r=0.78,P〈0.05）.Conclusion：OPN and IL-18 levels in peripheral blood of hepatitis B is closely related to the diseases degree,and there is a clinic significance of the levels of OPN and IL-18,which may be potent plasma markers.

关 键 词：乙型肝炎 慢性 肝硬化 骨桥蛋白 细胞因子/IL-18 

分 类 号：R575.1[医药卫生—消化系统]