实验性肝细胞癌SPIO增强MR成像序列的选择  

The choice of the sequence of MR enhanced with SPIO in experimental HCC

作　　者：廖翠薇[1] 邹利光[1] 卫静[1] 刘卫金[1] 梁开运[1] 

机构地区：[1]第三军医大学新桥医院放射科,重庆400037

出　　处：《西部医学》2009年第1期101-103,共3页Medical Journal of West China

摘　　要：目的评价不同SPIO增强MRI扫描序列在实验性肝细胞癌检查中的价值。方法建立80只大鼠肝细胞癌模型,大鼠分别于灌药后第16、18、20、21、22、23、24、25周行MRI扫描,先行SE-T1WI、FMPSPGR-T1WI、GRE-T2WI和FSE-PDWI、FSE-T2WI的MRI平扫检查,再采用相同序列和参数进行SPIO增强MRI检查,并选取兴趣区获取相关参数。结果SPIO增强后,肝组织信号在所有扫描序列上均降低,GRE-T2WI上肝组织的信号降低最显著,肝细胞癌的CNR最高,而FSE-PDWI上肝组织和肝细胞癌的SNR最高。结论GRE-T2WI、PDWI是实验性肝细胞癌SPIO增强MRI的较理想序列。Objective To evaluate the value of the different MR sequences in visualization of the rat with hepatocellular carcinoma rat after administration of superparamagnetie iron oxide （ SPIO）. Methods Experimental model of hepatocellular carcinoma was induced with DEA in 80 rats. MR imaging was performed before and after SPIO injection with SE-T1WI, FMPSPGR- T1WI, GRE-T2WI, FSE-PDWI and FSE-T2WI. The relative parameters of MR were obtained. Results After SPIO enhancement, the signal intensity of liver decreased in all sequences, the signal intensity loss of liver and the CNR of HCC in GRE- T2WI were significantly greater than those in other sequences, and the SNR of HCC or liver in FSE-PDWI was significantly higher than that in other sequences. Conclusion GRE-T2WI and FSE-PDWI were the preierred choice in SP10-enhanced MRI.

关 键 词：肝细胞癌 超顺磁性氧化铁 磁共振成像 序列 

分 类 号：R735.7[医药卫生—肿瘤]