“O”型口蹄疫病毒生物合成多肽苗的免疫效力  

IMMUNE EFFICIENCY OF BIOSYNTHETIC PEPTID VACCINE AGAINST SEROTYPE O FMDY

作　　者：徐泉兴[1] 尤永进[1] 赵洪兴[1] 饶忠[1] 乌正芳 周智爱[1] 盛祖恬[2] 何秉耀[2] 何永强[2] 杜青云[2] 郑兆鑫[3] 郭杰炎[3] 金建平[3] 

机构地区：[1]上海市农业科学院畜牧兽医研究所,上海201106 [2]浙江省农业科学院病毒研究所,杭州310021 [3]复旦大学,上海200433

出　　处：《上海农业学报》1998年第1期1-3,共3页Acta Agriculturae Shanghai

基　　金：国家科委与上海市科委共同资助!"八五"重点攻关项目

摘　　要：pXZ500生物合成多肽苗，用四个批次，分11个组别进行豚鼠实验室内免疫试验，保护率在80％以上，平均90％；用三个批次做猪的室内免疫试验，平均保护率在80％以上；用三个批次进行猪的田间试验，取回室内攻击，保护率也在80％以上。同一多肽苗在豚鼠与猪之间的免疫效果具有一致性。Guinea pigs of 11 groups were vaccinated in experiments,using 4 batches ofbiosynthetic peptid vaccine of pXZ500. After FMDV challenge exposure, the protection rateof guinea pigs is over 80% (average: 90%). Swine were vaccinated in experiments with 3batches of the same vaccine. After challenge exposure with FMDV, the average protectionrate of swine is over 80%. The field immune tests of swine were carried out with 3 batches ofbiosynthetic peptid vaccine. 4～5 swine of each group were randomly taken for challenge exposure with FMVD. The protection rate of swine is also over 80%. With the same biosynthetic peptid vaccine,the immune effects on guinea pig and swine are in agreement.

关 键 词：生物合成多肽苗 免疫效力 口蹄疫病毒 疫苗 

分 类 号：S852.52[农业科学—基础兽医学] S855.3[农业科学—兽医学]