石菖蒲α-细辛醚抗癫痫作用的实验研究  

Experimental study on the antiepileptic properties of alpha-asarone in different epilepsy models

作　　者：苗静琨[1] 吴小玫[1] 陈启雄[1] 张晓萍[1] 

机构地区：[1]重庆医科大学附属儿童医院新生儿科,重庆400014

出　　处：《中国药理学通报》2008年第12期1660-1662,共3页Chinese Pharmacological Bulletin

基　　金：重庆医科大学博士启动基金资助项目(No0200101060)

摘　　要：目的探讨石菖蒲成分α-细辛醚的抗癫痫作用。方法采用MES、MST及Lithium-pilocarpine模型;预先给予不同剂量的α-细辛醚,2次/d,连续28d,记录发作潜伏期、发作级别及惊厥动物数,对比观察α-细辛醚在控制3种模型癫痫发作中的疗效。结果石菖蒲α-细辛醚能对抗MES、MST模型小鼠及Lithium-pilocarpine模型大鼠的惊厥发作,抗惊厥率分别为40%～100%、50%～90%、40%～80%;能明显延长MST模型小鼠及Lithium-pilocarpine模型大鼠惊厥发作潜伏期,分别为70～180s和4～15min;并能降低Lithi-um-pilocarpine模型大鼠惊厥发作级别达1.96。结论石菖蒲α-细辛醚具有确切的抗癫痫作用,是一种广谱抗癫痫药。Aim To investigate the antiepileptic activity of alpha-asarone in three epilepsy models. Methods The MES mice, MST mice and Lithium-piloearpine rats were divided randomly and respectively into groups each containing 20 animals （α-asarone groups, AED groups and normal control group ）. Different doses of alpha-asarone were administered to mice/rats in advance in alpha-asarone treated groups, one group received only saline, while the other groups received antiepileptic drug as a reference standard,2 times per day for 28 days. The seizure severity score, seizure latency and total number of animals with seizures were noted to observe whether alpha-asarone had anticonvulsant effect or not in three epilepsy models. Results Alphaasarone possessed excellent anticonvulsant effect in MES and MST and lithium-pilocarpine models. It significantly decreased the seizure incidence 40% - 100% in the MES models and 50% - 90% in MST models, and 40% - 80% in the Lithium-pilocarpine model. It significantly prolonged the seizure latency 70 - 180 s in MST mice and 4 - 15 min in Lithium-pilocarpine rats;It significantly reduced the seizure severity seores 1.96 in Lithium-pilocarpine rats. Conclusions Alpha-asarone had a positive antiepileptic activity.

关 键 词：癫痫 Α-细辛醚 动物模型 抗癫痫作用 

分 类 号：R-332[医药卫生] R284.1