褐藻多糖硫酸酯的抗炎与抗氧化活性研究进展  

Fucoidan:advances in the study of it's anti-inflammatory and anti-oxidative effects

作　　者：崔艳秋[1] 罗鼎真[1] 王晓民[1] 

机构地区：[1]首都医科大学生理学系,教育部神经退变性疾病重点实验室,北京100069

出　　处：《药学学报》2008年第12期1186-1189,共4页Acta Pharmaceutica Sinica

基　　金：国家重点基础研究发展计划(973计划)资助项目(2006CB500700)

摘　　要：褐藻多糖硫酸酯是一种天然来源的海藻多糖,具有多种生物活性,尤其是抗炎和抗氧化应激活性近年来受到了研究者的广泛关注。研究表明,褐藻多糖硫酸酯可通过与细胞膜上的选择素结合而参与炎症的病理过程,也可作为清道夫受体的配体发挥抗炎症作用,它亦参与调节多种炎症相关因子的生成。褐藻多糖硫酸酯还可以抑制活性氧自由基的生成并促进其清除,从而表现出抗氧化活性。Fucoidan is a natural polysaccharide extracted from brown seaweeds, with a wide variety of biological features, especially the anti-inflammatory and anti-oxidative effects. Studies indicated that the anti-inflammatory effect of fucoidan related to its capacity to interact with the selectin or scavenger receptor on the cell membrane. Fucoidan can also inhibit the synthesis and release of reactive oxygen species （ROS）, as well as promote its clearance, showing the anti-oxidative activity.

关 键 词：褐藻多糖硫酸酯 抗炎活性 抗氧化活性 

分 类 号：R963[医药卫生—微生物与生化药学]