Methotrexate induced sprue-like syndrome  

作　　者：Marta Maia Boscá Ramon Aón Rosana Villagrasa Nelly Balza Cirilo Amorós Adolfo Benages Empar Mayordomo Juan Ramon Corts 

机构地区：[1]Gastroenterology Department, Hospital Clínic Universitari of València [2]Department of Anathomo-Pathology, Hospital Clínic Universitari of València [3]Rheumatology Department, Hospital Clínic Universitari of València

出　　处：《World Journal of Gastroenterology》2008年第45期7009-7011,共3页世界胃肠病学杂志（英文版）

摘　　要：A 52 year-old male patient diagnosed of ankylosing spon-dylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate. He did not respond to treatment with oral iron not a proton pump inhibitor and an upper endoscopy was performed. The histological study of the duodenal biopsies showed villus atrophy. After removing the methotrexate, administrating intra-muscular iron and undertaking a gluten-free diet, the histological and analytical alterations progressively resolved.A 52 year-old male patient diagnosed of ankylosing spondylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate. He did not respond to treatment with oral iron not a proton pump inhibitor and an upper endoscopy was performed. The histological study of the duodenal biopsies showed villus atrophy. After removing the methotrexate, administrating intramuscular iron and undertaking a gluten-free diet, the histological and analytical alterations progressively resolved.

关 键 词：METHOTREXATE Villous atrophy Iron deficiency anemia Paucisymptomatic Absence of celiac antibodies 

分 类 号：R595.3[医药卫生—内科学]