胰腺星状细胞与胰腺癌的相互关系  

Relationship between pancreatic stellate cells and pancreatic cancer

作　　者：倪建琦[1] 蒋小华[1] 汤文浩[1] 

机构地区：[1]东南大学附属中大医院普外科,江苏省南京市210009

出　　处：《世界华人消化杂志》2008年第33期3782-3786,共5页World Chinese Journal of Digestology

摘　　要：胰腺癌是一种恶性程度极高的消化系肿瘤,其生长速度快、转移早,对放射和化学治疗不敏感.胰腺癌重要的病理特征是癌组织周围有大量以成纤维细胞、胶原和纤维黏连蛋白等结缔组织聚集.目前已有文献报道,活化的胰腺星状细胞在其中起着重要的作用;更有研究认为,胰腺星状细胞在胰腺癌的发生、发展和转移中亦可能起到一定的作用.本文就胰腺星状细胞和胰腺癌细胞之间的相互关系及其在胰腺癌发展和转移中的作用作一综述.Pancreatic carcinoma is a highly malignant tumor in digestive tract,characterized by rapid progression,early metastasis,limited response to chemotherapy and radiotherapy,and an intense fibrotic reaction known as tumor desmoplasia.Carcinoma cells are surrounded by dense stroma consisting of myofibroblast-like cells,collagens,and fibronectin.Recent studies suggest that pancreatic stellate cells play an important role in this reaction and can stimulate pancreatic tumor cell proliferation,progression and metastasis.This review describes the discovery,activation pathway,interaction between pancreatic stellate cells and pancreatic tumor cells,and the role of pancreatic stellate cells in the process of pancreatic cancer initiation,progression,and metastasis.

关 键 词：胰腺星状细胞 胰腺癌 基质 

分 类 号：R576[医药卫生—消化系统] R735.9[医药卫生—内科学]