抑癌基因RUNX3与消化系肿瘤关系的研究进展  

Research progress in the relationship between RUNX3 gene and digestive system neoplasm

作　　者：陶军[1] 邓涛[1] 

机构地区：[1]武汉大学人民医院消化内科,湖北省武汉市430060

出　　处：《世界华人消化杂志》2008年第33期3787-3791,共5页World Chinese Journal of Digestology

摘　　要：抑癌基因RUNX3在胃癌中被发现以来,研究便集中在该基因与消化系肿瘤发生发展的关系,尤其是在胃癌、结直肠癌、食管癌、肝癌中.RUNX3基因甲基化可能与肿瘤发生相关,沉默的RUNX3基因重新表达能抑制肿瘤的生长,血浆中甲基化的RUNX3可能成为较敏感的标志物,对于提高消化系肿瘤的早期诊断率将有一定的临床意义.Since tumor suppressor gene RUNX3 was found in gastric cancer,researches have focused on the relationship between the gene and malignancies in digestive track,especially gastric carcinoma,colorectal carcinoma,esophageal carcinoma and liver carcinoma.The methylation of RUNX3 gene may correlate with the occurence of tumors.Silence of RUNX3 gene can suppress tumor growth,and methylated RUNX3 gene product in serum may be a sensitive tumor marker,which is of great significance in early diagnosis of digestive system neoplasm.

关 键 词：抑癌基因 RUNX3 消化系肿瘤 

分 类 号：R735[医药卫生—肿瘤]