氩离子凝固术在放大色素内镜下治疗胃黏膜癌前病变90例  

Argon plasma coagulation under magnifying chromoendoscopy for gastric premalignant lesions:an analysis of 90 cases

作　　者：袁海锋[1] 唐少波[1] 奚锦要[1] 

机构地区：[1]广西中医学院附属瑞康医院消化内科,广西壮族自治区南宁市530011

出　　处：《世界华人消化杂志》2008年第33期3805-3809,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨放大色素内镜下氩离子凝固术对胃黏膜癌前病变的治疗效果及其临床应用价值.方法:应用Fujinon EG-590ZW型电子放大内镜,结合美蓝染色,对90例胃黏膜癌前病变患者进行氩离子凝固术治疗,观察治疗前后病灶细微结构形态学改变,并结合其病理组织学改变进行比较分析.结果:90例伴随肠上皮化生及异型增生的胃黏膜在进行氩离子凝固术治疗后6 mo,胃小凹形态由治疗前的E、F型再生为C、D型(86.7%、6.7%),异常增生微血管消失,其相应病理组织学转变为慢性活动性炎症(85.6%)及萎缩性炎症(8.9%),E、F型胃黏膜及肠上皮化生、异型增生消融率分别为93.0%及94.4%.结论:氩离子凝固术是一种胃黏膜癌前病变安全、有效的治疗方法.AIM：To investigate the effects and clinical value of argon plasma coagulation（APC）on gastric premalignant lesions under magnifying chromoendoscopy（MCE）.METHODS：A total of 90 cases with gastric pre-malignant lesions underwent argon plasma co-agulation under magnifying chromoendoscopy using Fujinon EG-590ZW magnifying endoscope in combination with methylene blue staining.The changes of microstructures after treatment were studied and compared with histopathology.RESULTS：Six months after argon plasma co-agulation treatment,microstructures of gastric mucosa in 90 cases with intestinal metaplasia and dysplasia were regenerated from type E,F to type C or D（86.7%,6.7%）,and the abnormal hyperplasia blood capillary disappeared.Histo-pathological tissues changed into active inflam-mation（85.6%）or atrophic inflammation（8.9%）.The ablation rates of microstructures（type E and F）and histopathology（intestinal metaplasia and dysplasia）were 93.0%and 94.4%,respectively.CONCLUSION：Argon plasma coagulation is a safe and effective method in the treatment of gastric premalignant lesions.

关 键 词：放大色素内镜 氩离子凝固术 胃黏膜癌前病变 

分 类 号：R735.2[医药卫生—肿瘤]