康莱特抗癌症恶病质实验研究  

Experimental Study of the Counteractive Effect of Kanglaite on Cancer Cachexia

作　　者：李同度[1] 刘爱国[1] 牛旗 董慧明[1] 宋德胜 

机构地区：[1]安徽省肿瘤医院

出　　处：《中国肿瘤临床》1998年第2期131-133,共3页Chinese Journal of Clinical Oncology

摘　　要：研究通过Ｔ７３９小鼠接种ＬＡ７９５（小鼠肺腺癌）建立癌症恶病质动物模型，并采用康莱特对癌症恶病质鼠进行治疗，观察癌症恶病质鼠治疗后生理状况（体重、摄食量等）的改善及与癌症恶病质发生、发展相关的血清细胞因子如ＴＮＦ－α、ＩＬ－１和ＩＬ－６的水平变化。ＴＮＦ－α血清水平用ＲＩＡ检测，ＩＬ－１及ＩＬ－６用ＥＬＩＳＡ法。结果表明：与生理盐水治疗荷瘤小鼠相比，康莱特能明显阻止癌症恶病质鼠体重下降、增加其摄食量、延长生存期、延缓肿瘤生长、并使部分肿瘤液化、坏死。血清ＴＮＦ－α和ＩＬ－１水平同时也明显下降，实验所见均提示康莱特具有明显的抗癌症恶病质作用。This study was conducted to investigate the effect of Kanglaite (KLT) in the treatment of cancer cachexia by way of animal cancer cachexia model 　established by inoculating mice T739 with tumor LA795(lung adenocarcinoma). Observations were made on the improvement of physiologial conditions (body weight, food intake etc.) of the cachectic mice following treatment, and also of the continuing changes in levels of serum cytokines such as TNFα,IL1 and IL6, which are considered to correlate with the occurrence and development of cancer cachexia. The 　serum level of TNFα was assayed by RIA, and those of IL1 and IL6 by ELISA method . The results showed that the administration of KLT to cancer cachectic mice significantly inhibited the loss of body weight, increased food intake, prolonged life span, inhibited tumor growth and in several mice even caused liquefaction and necrosis of tumor. The serum levels of TNFα and IL1 also declined substantially 　in comparison with the normalsaline treated tumor bearing mice. All the above 　findings strongly suggested that KLT possesses significant counteractive effect on 　cancer cachexia. 

关 键 词：康莱特 体重 摄食量 恶性肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]