子宫颈小细胞癌18例临床病例分析  

Clinical analysis of 18 cases of small cell carcinoma of the cervix

作　　者：李虎[1,2] 刘继红[1,2] 熊樱[1,2] 李明伟[1,2] 关明飞[1,2] 

机构地区：[1]华南肿瘤学国家重点实验室,广东广州510060 [2]中山大学肿瘤防治中心妇科,广东广州510060

出　　处：《实用肿瘤杂志》2008年第6期536-539,共4页Journal of Practical Oncology

摘　　要：目的探讨子宫颈小细胞癌(SCCC)的临床特点及预后因素。方法对18例SCCC,回顾性总结分析其临床、病理及随访资料。结果本组18例患者的中位年龄为42.5岁(24～65岁)。7例子宫颈伴有其它类型的癌。16例患者行子宫颈癌根治术,6例患者保留一侧卵巢,未见卵巢部位复发。9例有盆腔淋巴结转移,7例治疗后发生远处转移。18例患者中位生存期22个月,总的2年和5年生存率分别为44.4和22.2。16例手术患者9例接受过放疗和7例未接受放疗患者的复发率分别为44.4(4/9)和28.6(2/7)(P=0.039),5年生存率分别为33.3(3/9)和14.3(1/7)(P=0.002)。16例患者1例未接受术后化疗,40周后死亡。结论SCCC预后差,易复发和转移。辅助放疗、化疗可能会提高患者的生存率。Objective To investigate the cIinical features,the prognostic factors and treatment of small cell carcinoma of the cervix（SCCC）. Methods The clinicopathological data of 18 cases with SCCC were reviewed and analyzed retrospectively. Results The median age of this group of patients was 42.5 years （24-65）. Seven cases had other types of malignancies in the cervix. Sixteen cases underwent radical surgery. Unilateral ovary was reserved in six cases, and there was no ovarian recurrence. Nine cases had pelvic lymph node involvement. Seven cases had remote site recurrence. The median survival was 22 months,and 2-year and 5-year survival rates were 44. 4% and 22. 2%,respectively. The recurrence rate for patients receiving radiotherapy was 44.4% （4/9） and for those not receiving radiotherapy was 28. 6% （2/7）（P = 0. 039）;the 5-year survival rate of them was 33. 3%（3/9） and 14. 3%（1/7）, respectively （P = 0. 039）. One case who did not receive chemotherapy died in 40 weeks. Conclusions The outcome of SCCC is very poor; recurrence and metastasis are common. Adjuvant radiotherapy and chemotherapy may prolong the 5-year survival rate.

关 键 词：宫颈肿瘤/治疗 宫颈肿瘤/诊断 癌 小细胞 神经内分泌瘤 预后 淋巴转移 

分 类 号：R737.33[医药卫生—肿瘤]