癌症患者血清硒和全血GSH-PX的临床研究  

Serum Selenium and Blood Glutathione Peroxidase in Cancer Patients

作　　者：南克俊[1] 薛峰杰[1] 杨世勇[1] 董青[1] 

机构地区：[1]西安医科大学第一临床医学院肿瘤内科

出　　处：《中国肿瘤临床》1998年第1期51-53,共3页Chinese Journal of Clinical Oncology

摘　　要：测定８９例癌症患者血清硒（ＳＳｅ）和全血谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）活性，并与３１例健康人进行对照，以探讨ＳＳｅ与ＧＳＨ－ＰＸ间的相互关系和临床意义。结果示ＳＳｅ与ＧＳＨ－ＰＸ活性明显低于对照组（Ｐ＜０．０１和Ｐ＜０．０５），ＳＳｅ和ＧＳＨ－ＰＸ呈显著正相关。随着临床分期不同，ＳＳｅ和ＧＳＨ－ＰＸ活性下降趋于明显，Ⅲ～Ⅳ期明显低于Ⅰ－Ⅱ期（Ｐ＜０．０５）；不同部位癌症患者之间ＳＳｅ和ＧＳＨ－ＰＸ活性均无显著性差异（Ｐ＞０．５）。Serum selenium (SSe) concentration and whole blood glutathione peroxidase (GSHPX) activity were measured in 89 cancer patients and　31 healthy individuals as control aiming to study the correlation　between SSe and GSHPX activity and their clinical significance.The results　showed that SSe level and GSHPX in cancer patients were significantly lower　than those in the control group(P<0.01 and P<0.05 respectively).It was found　that SSe was remarkably correlated with GSHPX activity in both groups(r=0.69,P<0.01 and r=0.65,P<0.01).The SSe and GSHPX activity declined along with the　escalation of the clinical stage of the tumor,but there was no prominent　difference between SSe level and GSHPX activity in patients with different　tumor sites.The study suggests that SSe level and GSHPX activity correlate　well with the progress of the cancer.

关 键 词：硒 谷胱甘肽 过氧化物酶 肿瘤 血清诊断 

分 类 号：R730.43[医药卫生—肿瘤]