结直肠癌中p53蛋白和Ki67的表达及临床意义  

Expression and clinic significance of p53 and Ki67 in colorectal cancer

作　　者：侯慧[1] 肖明明[1] 任秋华[1] 郑静[1] 

机构地区：[1]辽宁省人民医院病理科,沈阳110016

出　　处：《实用肿瘤学杂志》2008年第5期424-426,共3页Practical Oncology Journal

摘　　要：目的探讨p53蛋白和Ki67在结直肠癌中的表达及临床病理学意义。方法应用免疫组织化学的方法检测80例结直肠癌和癌周黏膜组织中p53蛋白和Ki67表达。结果p53蛋白和Ki67在结直肠癌中表达阳性率分别为(85%,90%),癌旁组织阳性率分别为(88.2%,88.2%);正常结直肠组织中p53无蛋白表达,Ki67蛋白可见表达。p53蛋白在结直肠癌中的表达与分化程度有显著差异(P(0.01),具有统计学意义,Ki67在结直肠癌中表达与分化程度无显著差异(P(0.05),不具统计学意义。结论p53蛋白的表达与结直肠癌的发生发展有关,表达强度与癌组织的分化程度、浸润深度、转移及预后有关,Ki67的表达与结直肠癌的发生发展有关,表达强度与癌组织的分化程度浸润深度转移及预后无相关性。p53蛋白可作为评估患者预后的指标,Ki67是评估细胞增殖的较好指标,并不能作为评估患者预后的指标。Objective To discuss clinic significance of the expression of p53 and Ki67 . Method Using immunohistochemistry to detect the expression of p53 and Ki67 of eoloreetal cancer and peri-cancer tissue. Results The positive rate of p53 and Ki67 in colorectal cancer are 85% and 90% respectively, which of peficancer tissue are 88.2% and 88.2% respectively; nonexpression of 1：63 in normal colorectum, but Ki67 is posi- tive. The expression of Ki67 in colorectal cancer has no significant deviation with differentiation（ P 〉0.05 ）. Conclusion The expression of p53 is relevant to the generation and development of colorectal cancer, and the inten- sity of the expression is relevant to the differentiation, the depth of infiltration, metastasis and prognosis. The ex- pression of Ki67 is also relevant to the generation and development of colorectal cancer, but the intensity of the ex- pression is not relevant to the differentiation, the depth of infiltration, metastasis and prognosis, p53 could be an index appraising prognosis. Ki67 is also a good index estimating proliferation, but couldn＇ t be index appraising prognosis.

关 键 词：结直肠癌 P53 KI67 免疫组织化学 

分 类 号：R735.35[医药卫生—肿瘤] R392.31[医药卫生—临床医学]