MMP-3和p53蛋白在乳腺癌组织中的表达及其与肿瘤转移的关系  

Expression and clinical significance of MMP-3 and p53 in mammary carcinoma

作　　者：肖敏[1] 黄孙卉[2] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,哈尔滨150081 [2]哈尔滨医科大学肿瘤防治研究所

出　　处：《实用肿瘤学杂志》2008年第6期514-516,共3页Practical Oncology Journal

摘　　要：目的细胞外基质金属蛋白酶-3(MMP-3)和p53在乳腺癌组织中的表达及临床意义。方法采用免疫组化S-P法检测58例临床资料完整的乳腺癌组织标本中MMP-3和p53的表达情况并进行对比观察,结合临床资料作统计学分析。结果58例乳腺癌组织中MMP-3的阳性表达为44.83%,MMP-3的高表达与肿瘤的淋巴结转移呈正相关,P<0.05;p53的阳性表达为37.93%,其表达与肿块大小有相关性,P<0.05。结论MMP-3和p53在乳腺浸润性导管癌中的表达可以作为估计乳腺癌预后及术后综合治疗的生物学指标。Objective To study the significance of MMP - 3 and p53 expression in patients with mam- mary carcinoma. Methods The expression of MMP - 3 and p53 were detected by immunohistoehemical S - P in 58 mammary infiltration duct carcinoma tissue samples and their clinical data were statistically analysed. Results In 58 mammary carcinoma tissue samples,the expression of MMP -3 was 44.83% and the expression of p53 was 37.93%. The expression of MMP - 3 was correlated significantly with lymph node metastasis, P 〈 0.05 ; The expression of p53 was correlated significantly with the size of cancer ,P 〈 O. 05. Conclusions The expression of MMP- 3, p53 can be taken as the biological marker of prognosis and postoperative comprehensive treatment of breast cancer.

关 键 词：乳腺浸润性导管癌 MMP-3 P53 

分 类 号：R737.9[医药卫生—肿瘤]