乙酰甲胺磷对雄性大鼠睾丸组织抗氧化能力的影响  

Effect of Acephate on the Capability of Anti-oxidizing in Testis of Male Rats

作　　者：宁艳花[1] 刘秀芳[1] 薛亚斌[1] 关素珍[1] 刘桂珠[1] 

机构地区：[1]宁夏医学院公共卫生学院环境卫生学与毒理学教研室,银川750004

出　　处：《宁夏医学院学报》2008年第6期726-728,共3页Journal of Ningxia Medical College

基　　金：2006年宁夏自然自学基金资助项目(NZ0662)

摘　　要：目的探讨乙酰甲胺磷对雄性大鼠睾丸组织抗氧化能力的影响。方法24只健康成年SD雄性大鼠,随机分为4组,每组6只。阴性对照组(蒸馏水)和3个不同剂量乙酰甲胺磷染毒组(11.81、23.63、47.25 mg/kg.bw),采用经口灌胃染毒方式,共染毒60d。检测睾丸组织氧化损伤指标SOD和GSH-Px活性、GSH和MDA的含量。结果乙酰甲胺磷各染毒组睾丸组织匀浆中SOD和GSH-Px活力均呈现剂量反应关系,其中高剂量染毒组低于阴性对照组(P<0.05)。结论乙酰甲胺磷在47.25 mg/kg剂量下,对雄性大鼠睾丸抗氧化功能有一定的抑制作用。Objective To explore the effect on the capability of anti-oxidizing in testis of male rats. Methods Different doses of acephate（0, 11.81, 23.63, 47.25 mg/kg-bw）were orally treated to the adult male SD rats for 60 days. Then the activities of SOD and GSH-Px, the level of GSH and MDA were determined. Results The activities of SOD and GSH-Px in testis homogenate decreased with dose increasing, and significant difference was found between high dosage group and negative group（ P 〈 0.05）. Conclusion The results suggest that aeephate at the close of 47.25 mg/kg· bw can inhibit the antioxidan function of the testis.

关 键 词：乙酰甲胺磷 大鼠 睾丸 抗氧化功能 

分 类 号：R114[医药卫生—卫生毒理学]