未行淋巴清扫的早期卵巢癌81例生存率的回顾性分析  

Retrospective analysis of survival in 81 women with early epithelial ovarian carcinoma who had not undergone systematic lymphadenectomy

作　　者：陈金虹[1] Karen KL CHAN Kar Fai TAM Hextan YS NGAN 

机构地区：[1]上海交通大学医学院附属国际和平妇幼保健院,上海200030 [2]香港大学玛丽医院妇产科

出　　处：《肿瘤》2008年第12期1059-1063,共5页Tumor

摘　　要：目的:探讨对于因各种原因而未行淋巴清扫的早期卵巢癌患者,若不行二次分期手术,而是给予辅助化疗,其生存率是否会受影响。方法:收集1992年1月—2002年12月所有在香港玛丽医院妇产科就治的、因各种原因未接受淋巴清扫的、肉眼直视观察肿瘤局限于卵巢的Ⅰ期卵巢癌病例进行回顾性分析。结果:有81例患者被纳为研究对象,其中ⅠA期23例,ⅠB期1例,ⅠC期57例。年龄范围21～81岁,平均年龄47岁。随访时间50～179个月,平均随访时间为110个月。其中有64例(79.0%)患者接受了辅助化疗。总的5年生存率和4年无瘤生存率分别为91.4%和85.2%,与文献报道的行淋巴清扫后的结果相近。结论:对于未行淋巴清扫而病变局限于卵巢的Ⅰ期卵巢癌患者,若辅以适当的化疗,可以使她们获得与行淋巴清扫患者同样的生存率。Objective：This study aims to investigate whether postoperative adjuvant chemotherapy had any influence on the survival rate of those women with early ovarian carcinoma who did not receive pelvic lymphadenectomy and secondary surgery. Methods： This work conducted a retrospective review on all apparently stage I epithelial ovarian carcinoma patients who had not undergone lymphadenectomy in Queen Mary hospital, Hong Kong, within a ten-year period, from January of 1992 to December of 2002. Results： This work collected the clinical data from 81 patients. Twenty-three patients were apparently at stage IA, 1 patient at stage IB, and 57 patients at stage IC. The mean age was 47 years old （21-81 years） and the median follow-up period was 110 months （50-179 months）. Totally 64 （79.0%） patients received adjuvant chemotherapy. The 5-year overall survival rate was 91.4% and 4-year progression free survival rate was 85.2%, which were similar to the survival rates described in the literature for patients who had undergone systematic lymphadenectomy. Conclusion ： With provision of appropriate adjuvant chemotherapy, women with apparent stage I disease who have not undergone pelvic lymphadenectomy may achieve similar long-term survival rate to those who have undergone systematic lymphadectomy.

关 键 词：淋巴结切除术 卵巢肿瘤 生存率 

分 类 号：R737.31[医药卫生—肿瘤] R730.56[医药卫生—临床医学]