载脂蛋白E ε4和ε2等位基因与胎儿宫内发育的关系  

Relationship between apolipoprotein E ε4, ε2 alleles and intrauterine growth

作　　者：郭峰 张振馨 许群[2] 张俊武[2] 赵华路[2] 

机构地区：[1]中国医学科学院北京协和医院神经科临床流行病室,100730 [2]中国医学科学院基础医学研究所生物化学及分子生物学系

出　　处：《中华神经科杂志》2008年第12期835-839,共5页Chinese Journal of Neurology

基　　金：美国国立卫生研究院-老年医学研究所（NIH-NIA）基金资助项目（P015P01AG17937-03）;美国中华医学基金会项目（99-699） 志谢 感谢中国医学科学院北京协和医院神经科张俊宝、李延峰、周涌涛、何小明、胡洪涛、温洪波、马玉梅、牛富生、袁晶、李凌、王赵和石秉炀等同事给予的大力帮助

摘　　要：目的研究载脂蛋白E（ApoE）ε4和ε2等位基因与胎儿宫内发育的关系。方法以聚合酶链反应．限制性片段长度多态性分析（PCR-RFLP）方法检测1418名北京协和医院出生人群的ApoE基因型，计算等位基因频率，收集其出生时的相关指标。通过单因素分析和多因素Logistic回归分析比较ApoE ε4和ε2等位基因与新生儿发育状态的关系。结果本研究人群中ApoE ε2、ε3和ε4等位基因频率分别为8．11％、83．39％和8．50％。单因素分析结果表明，携带82等位基因者的出生体质量指数（ponderal index，PI）构成差异有统计学意义（χ^2=4．87，P=0．027），其头围、胎盘质量和孕周构成差异没有统计学意义。多因素分析结果表明，调整了性别、年龄、出生头围、胎盘质量、孕周、产次和产妇年龄等因素，携带ApoE ε2等位基因与小PI呈负相关（χ^2=5．077，P=0．024）。没有发现携带ApoE ε4等位基因与新生儿发育状态存在关联性。结论ApoE ε2等位基因对PT有保护作用，没有发现ApoE ε4等位基因与胎儿宫内发育有关。Objective To investigate the relationship between apolipoprotein E ApoE） ε4, ε2 alleles and intrauterine growth. Methods ApoE genotypes of 1418 people born in Peking Union Medical College Hospital were analyzed, allele frequencies were calculated and their parameters at birth were collected. To compare ApoE ε4, ε2 alleles with parameters at birth through single factor analysis and Logistic regression analysis. Results The allelic frequencies of ε2, ε3 and ε4 were 8. 11% , 83.39% and 8. 50% in the group. The results of single factor analysis showed that there was significant difference between the distribution of ponderal index （PI） in the ApoE ε2 allele group （χ^2 = 4. 87, P = 0. 027 ）. While there was no significant difference between the distribution of head circumference at birth, placental weight and gestational age in the ApoE ε2 allele group. ApoE ε2 allele showed negative correlation with small PI in the logistic regression analysis （χ^2 = 5. 077,P = 0. 024）, after adjusted for gender, age, head circumference at birth, placental weight, gestational age, parity and maternal age at delivery. No association between ApoE ε4 allele and parameters at birth was found. Conclusions ApoE ε2 allele may have protective effect on PI. No association was found between ApoE ε4 allele and intrauterine growth.

关 键 词：阿尔茨海默病 胎儿发育 载脂蛋白E类 等位基因 人体质量指数 

分 类 号：R686[医药卫生—骨科学]