脑膜瘤磁共振波谱Cho/Cr比值与Ki-67核抗原表达的相关性研究  

Correlation study between Cho/Cr value of MRS and Ki-67 labeling index in meningiomas

作　　者：史瑞华[1] 翟仁友[1] 钱晓军[1] 鲁万红[1] 顾华[1] 

机构地区：[1]首都医科大学附属北京朝阳医院放射科,北京100020

出　　处：《中国临床医学影像杂志》2008年第12期855-857,868,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:探讨良、恶性脑膜瘤磁共振波谱(1H-MRS)Cho/Cr比值与Ki-67核抗原表达的相关性。方法:经手术病理证实的36例脑膜瘤在治疗前行常规MRI及1H-MRS检查(脑膜瘤I级30例,Ⅱ+Ⅲ级6例)。1H-MRS检查包括PRESS35、PRESS144序列。结果:良性脑膜瘤组Cho/Cr比值3.80±1.08;恶性脑膜瘤组为7.22±0.70。差异具有显著性(t=7.40,P=0.000)。良性脑膜瘤组Ki-67积分光密度6.43±1.09;恶性脑膜瘤组为12.15±4.14。相关性分析表明,Ki-67表达与Cho/Cr呈显著正相关(r=0.832,P=0.000)。MRS表现:本组脑膜瘤病例Cho峰升高,Cr降低。结论:脑膜瘤MRSCho/Cr比值与Ki-67表达具有相关性,是预测肿瘤增殖活性的有价值的指标,有助于脑膜瘤病理分级。Objective： To investigate the correlation between Cho/Cr value of ＇H magnetic resonance spectroscopy（1H-MRS） and the Ki-67 labeling index in meningiomas. Methods： Thirty-six patients with meningioma underwent conventional MR and 1H-MRS before operation （Grade Ⅰ 30 cases; Grade Ⅱ＋Ⅲ 6 cases）. 1H-MRS sequences included PRESS 35, PRESS 144. Expression of Ki-67 nuclear antigen were detected by immunohistochemical method of streptavidin-biotin-peroxidase（SP）. Results： The mean Cho/Cr ratio in the benign and malignant groups were 3.80±1.08 and 7.22±0.70, respectively（t=7.40, P=0.000）. Ki- 67 in the benign and malignant groups were 6.43±1.09 and 12.15±4.14, respectively. A significant linear correlation was observed between the Cho/Cr ratio and the expression of Ki-67. The MRS features of meningiomas were as follow： Cho increased markedly, Cr decreased evidently. Conclusion：1H-MRS is a useful diagnostic method for determining the proliferation or malignant potential of meningiomas according to the Cho/Cr ratio and the latter is correlated to the Ki-67 value.

关 键 词：脑膜瘤 KI-67抗原 磁共振波谱学 

分 类 号：R739.45[医药卫生—肿瘤] R445.2[医药卫生—临床医学]